Interleukin 15: a proinflammatory role in rheumatoid arthritis synovitis

被引：133

作者：

McInnes, IB ^{[1
]}

Liew, FY

机构：

[1] NIH, Arthrit & Rheumatism Branch, Bethesda, MD 20892 USA

[2] Royal Infirm, Ctr Rheumat Dis, Glasgow G31 2ER, Lanark, Scotland

[3] Univ Glasgow, Dept Immunol, Glasgow G12 8QQ, Lanark, Scotland

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 02期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0167-5699(97)01205-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In rheumatoid arthritis (RA), locally produced interleukin 15 (IL-15) can recruit and activate synovial T cells, which then amplify and perpetuate inflammation through induction of monocyte-derived tumour necrosis factor alpha (TNF-alpha) via a cell-contact-dependent mechanism. Thus, IL-15 could play a pivotal role in disease pathogenesis, acting upstream of TNF-alpha in orchestrating the induction of a cascade of inflammatory cytokines.

引用

页码：75 / 79

页数：5

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