Transcriptional mechanisms of hippocampal aging

被引：17

作者：

Lund, PK

Hoyt, EC

Bizon, J

Smith, DR

Haberman, R

Helm, K

Gallagher, M

机构：

[1] Univ N Carolina, Dept Cellular & Mol Physiol, Chapel Hill, NC 27599 USA

[2] Texas A&M Univ, Dept Psychol, College Stn, TX 77843 USA

[3] Johns Hopkins Univ, Neurogenet & Behav Ctr, Baltimore, MD 21218 USA

来源：

EXPERIMENTAL GERONTOLOGY | 2004年 / 39卷 / 11-12期

关键词：

transcription factor; CREB; glucocorticoid receptor; mineralocorticoid receptor; array; microarray; activator protein-1; chromatin; chromatin immunoprecipitation;

D O I：

10.1016/j.exger.2004.06.018

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging related cognitive decline is an increasing health problem but affects only a subset of elderly humans. This research uses outbred young (Y) and aged rats. Behavioral characterization distinguishes aged rats with impaired spatial learning (AI) and aged rats with unimpaired learning ability (AU), mimicking the varied susceptibility of the human population to age-associated learning impairment. Studies are testing a hypothesis that hippocampal transcriptional mechanisms and gene expression profiles linked to activator protein-1 (AP-1) and glucocorticoid receptor (GR), mineralocorticoid receptor (MR) or cyclic AMP response element binding protein (CREB) families of transcription factors distinguish successful or unsuccessful aging and cognition. Results from mRNA assays, in situ hybridization, electromobility shift assays and western immunoblot indicate changes in GR and CREB in AI rats. State of the art future approaches to define downstream transcription targets are described. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：1613 / 1622

页数：10

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[31] Increase in Bcl-2 phosphorylation and reduced levels of BH3-only Bcl-2 family proteins in kainic acid-mediated neuronal death in the rat brain [J].