Tetraspanins as Potential Therapeutic Candidates for Targeting Flaviviruses

被引：17

作者：

Ahmed, Waqas ^{[1
,3
]}

Neelakanta, Girish ^{[1
,2
,3
]}

Sultana, Hameeda ^{[1
,2
,3
]}

机构：

[1] Old Dominion Univ, Dept Biol Sci, Norfolk, VA 23529 USA

[2] Old Dominion Univ, Ctr Mol Med, Norfolk, VA 23529 USA

[3] Univ Tennessee, Coll Vet Med, Dept Biomed & Diagnost Sci, Knoxville, TN 37996 USA

来源：

FRONTIERS IN IMMUNOLOGY | 2021年 / 12卷

关键词：

tetraspanins; arthropods; flaviviruses; exosomes; transmission; ncRNAs;

D O I：

10.3389/fimmu.2021.630571

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Tetraspanin family of proteins participates in numerous fundamental signaling pathways involved in viral transmission, virus-specific immunity, and virus-mediated vesicular trafficking. Studies in the identification of novel therapeutic candidates and strategies to target West Nile virus, dengue and Zika viruses are highly warranted due to the failure in development of vaccines. Recent evidences have shown that the widely distributed tetraspanin proteins may provide a platform for the development of novel therapeutic approaches. In this review, we discuss the diversified and important functions of tetraspanins in exosome/extracellular vesicle biology, virus-host interactions, virus-mediated vesicular trafficking, modulation of immune mechanism(s), and their possible role(s) in host antiviral defense mechanism(s) through interactions with noncoding RNAs. We also highlight the role of tetraspanins in the development of novel therapeutics to target arthropod-borne flaviviral diseases.

引用

页数：13

共 110 条

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