A convenient synthesis of trisubstituted pyrido[2,3-d]pyrimidin-7-ones

被引：23

作者：

Kasparec, J

Adams, JL

Sisko, J

Silva, DJ

机构：

[1] GlaxoSmithKline, Dept Med Chem, Collegeville, PA 19426 USA

[2] GlaxoSmithKline, Dept Synthet Chem, King Of Prussia, PA 19406 USA

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 24期

关键词：

D O I：

10.1016/S0040-4039(03)00974-2

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel, highly efficient and scalable route for the synthesis of trisubstituted pyrido[2,3-d]pyrimidin-7-ones was developed. The target compounds were synthesized in five steps from readily available reagents in about 40% overall yield. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：4567 / 4570

页数：4

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