Rapid transit in the immune cells: the role of mRNA turnover regulation

被引：37

作者：

Khabar, Khalid S. A. ^{[1
]}

机构：

[1] King Faisal Specialist Hosp & Res Ctr, Program Biomol Res, Riyadh 11211, Saudi Arabia

来源：

JOURNAL OF LEUKOCYTE BIOLOGY | 2007年 / 81卷 / 06期

关键词：

mRNA stability; post-trancriptional regulation; cytokines;

D O I：

10.1189/jlb.0207109

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

There have been recent, significant advances about the role of mRNA turnover in controlling gene expression in immune cells. Posttranscriptional regulation of gene expression contributes to the characteristics of many of the processes underlying the immune response by ensuring early, rapid, and transient action. The emphasis of this review is on current work that deals with the regulation of mRNA decay during innate immunity against microbes and T cell activation as a model of the adaptive response.

引用

页码：1335 / 1344

页数：10

共 103 条

[1] Pathogen recognition and innate immunity [J].

Akira, S ;

Uematsu, S ;

Takeuchi, O .

CELL, 2006, 124 (04) :783-801

[2] Neutrophil signaling pathways activated by bacterial DNA stimulation [J].

Alvarez, Maria E. ;

Bass, Juan I. Fuxman ;

Geffner, Jorge R. ;

Fernandez Calotti, Paula X. ;

Costas, Mnica ;

Coso, Omar A. ;

Gamberale, Romina ;

Vermeulen, Monica E. ;

Salamone, Gabriela ;

Martinez, Diego ;

Tanos, Tamara ;

Trevani, Analia S. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (06) :4037-4046

[3] RNA granules [J].

Anderson, P ;

Kedersha, N .

JOURNAL OF CELL BIOLOGY, 2006, 172 (06) :803-808

[4] Posttranscriptional regulation of TNFα expression via eukaryotic initiation factor 4E (eIF4E) phosphorylation in mouse macrophages [J].

Andersson, K ;

Sundler, R .

CYTOKINE, 2006, 33 (01) :52-57

[5]

Atasoy U, 1998, J CELL SCI, V111, P3145

[6] ARED 3.0: the large and diverse AU-rich transcriptome [J].

Bakheet, Tala ;

Williams, Bryan R. G. ;

Khabar, Khalid S. A. .

NUCLEIC ACIDS RESEARCH, 2006, 34 :D111-D114

[7] AU-rich elements and associated factors: are there unifying principles? [J].

Barreau, C ;

Paillard, L ;

Osborne, HB .

NUCLEIC ACIDS RESEARCH, 2005, 33 (22) :7138-7150

[8] The Toll-like receptors: analysis by forward genetic methods [J].

Beutler, B .

IMMUNOGENETICS, 2005, 57 (06) :385-392

[9] Predictors of drug use among South African adolescents [J].

Brook, JS ;

Morojele, NK ;

Pahl, K ;

Brook, DW .

JOURNAL OF ADOLESCENT HEALTH, 2006, 38 (01) :26-34

[10] The role of mRNA turnover in the regulation of tristetraprolin expression: Evidence for an extracellular signal-regulated kinase-specific, AU-Rich element-dependent, autoregulatory pathway [J].

Brooks, SA ;

Connolly, JE ;

Rigby, WFC .

JOURNAL OF IMMUNOLOGY, 2004, 172 (12) :7263-7271

← 1 2 3 4 5 6 7 8 9 10 →