The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

被引：126

作者：

Burda, P. ^{[1
,2
]}

Laslo, P. ^{[3
]}

Stopka, T. ^{[1
,2
,4
]}

机构：

[1] Charles Univ Prague, Dept Pathophysiol, Fac Med 1, Prague 12853 2, Czech Republic

[2] Charles Univ Prague, Ctr Expt Hematol, Fac Med 1, Prague 12853 2, Czech Republic

[3] Univ Leads, Sect Expt Haematol, Leeds Inst Mol Med, St Jamess Univ Hosp, Leeds, W Yorkshire, England

[4] Gen Univ Hosp, Dept Med Hematol 1, Prague, Czech Republic

来源：

LEUKEMIA | 2010年 / 24卷 / 07期

基金：

英国惠康基金;

关键词：

PU.1; leukemia differentiation; GATA-1; chromatin; differentiation therapy; ACUTE MYELOID-LEUKEMIA; LINEAGE COMMITMENT; RETINOIC ACID; C/EBP-ALPHA; HISTONE DEACETYLASE; GENE-EXPRESSION; STEM-CELLS; TERMINAL DIFFERENTIATION; ERYTHROLEUKEMIA-CELLS; REGULATORY NETWORK;

D O I：

10.1038/leu.2010.104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed. Leukemia (2010) 24, 1249-1257; doi:10.1038/leu.2010.104; published online 3 June 2010

引用

页码：1249 / 1257

页数：9

共 108 条

[1] RETINOIC ACID RECEPTORS AND RETINOID X-RECEPTORS - INTERACTIONS WITH ENDOGENOUS RETINOIC ACIDS [J].

ALLENBY, G ;

BOCQUEL, MT ;

SAUNDERS, M ;

KAZMER, S ;

SPECK, J ;

ROSENBERGER, M ;

LOVEY, A ;

KASTNER, P ;

GRIPPO, JF ;

CHAMBON, P ;

LEVIN, AA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (01) :30-34

[2] Reciprocal activation of GATA-1 and PU.1 marks initial specification of hematopoietic stem cells into myeloerythroid and myelolymphoid lineages [J].

Arinobu, Yojiro ;

Mizuno, Shin-ichi ;

Chong, Yong ;

Shigematsu, Hirokazu ;

Lino, Tadafumi ;

Iwasaki, Hiromi ;

Graf, Thomas ;

Mayfield, Robin ;

Chan, Susan ;

Kastner, Philippe ;

Akashi, Koichi .

CELL STEM CELL, 2007, 1 (04) :416-427

[3] Visualizing PU.1 activity during hematopoiesis [J].

Back, J ;

Allman, D ;

Chan, S ;

Kastner, P .

EXPERIMENTAL HEMATOLOGY, 2005, 33 (04) :395-402

[4] c-Jun is a JNK-independent coactivator of the PU.1 transcription factor [J].

Behre, G ;

Whitmarsh, AJ ;

Coghlan, MP ;

Hoang, T ;

Carpenter, CL ;

Zhang, DE ;

Davis, RJ ;

Tenen, DG .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (08) :4939-4946

[5] Epigenetic and chromatin modifiers as targeted therapy of hematologic malignancies [J].

Bhalla, KN .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (17) :3971-3993

[6] CREB-binding protein cooperates with transcription factor GATA-1 and is required for erythroid differentiation [J].

Blobel, GA ;

Nakajima, T ;

Eckner, R ;

Montminy, M ;

Orkin, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (05) :2061-2066

[7] EKLF restricts megakaryocytic differentiation at the benefit of erythrocytic differentiation [J].

Bouilloux, Fabrice ;

Juban, Gaetan ;

Cohet, Nathalie ;

Buet, Dorothee ;

Guyot, Boris ;

Vainchenker, William ;

Louache, Fawzia ;

Morle, Francois .

BLOOD, 2008, 112 (03) :576-584

[8] PU.1 Activation Relieves GATA-1-Mediated Repression of Cebpa and Cbfb during Leukemia Differentiation [J].

Burda, Pavel ;

Curik, Nikola ;

Kokavec, Juraj ;

Basova, Petra ;

Mikulenkova, Dana ;

Skoultchi, Arthur I. ;

Zavadil, Jiri ;

Stopka, Tomas .

MOLECULAR CANCER RESEARCH, 2009, 7 (10) :1693-1703

[9] Coregulation of GATA factors by the Friend of GATA (FOG) family of multitype zinc finger proteins [J].

Cantor, AB ;

Orkin, SH .

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2005, 16 (01) :117-128

[10] Antagonism of FOG-1 and GATA factors in fate choice for the mast cell lineage [J].

Cantor, Alan B. ;

Iwasaki, Hirorni ;

Arinobu, Yojiro ;

Moran, Tyler B. ;

Shigematsu, Hirokazu ;

Sullivan, Matthew R. ;

Akashi, Koichi ;

Orkin, Stuart H. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2008, 205 (03) :611-624

← 1 2 3 4 5 6 7 8 9 10 →