The role of PU.1 and GATA-1 transcription factors during normal and leukemogenic hematopoiesis

被引：126

作者：

Burda, P. ^{[1
,2
]}

Laslo, P. ^{[3
]}

Stopka, T. ^{[1
,2
,4
]}

机构：

[1] Charles Univ Prague, Dept Pathophysiol, Fac Med 1, Prague 12853 2, Czech Republic

[2] Charles Univ Prague, Ctr Expt Hematol, Fac Med 1, Prague 12853 2, Czech Republic

[3] Univ Leads, Sect Expt Haematol, Leeds Inst Mol Med, St Jamess Univ Hosp, Leeds, W Yorkshire, England

[4] Gen Univ Hosp, Dept Med Hematol 1, Prague, Czech Republic

来源：

LEUKEMIA | 2010年 / 24卷 / 07期

基金：

英国惠康基金;

关键词：

PU.1; leukemia differentiation; GATA-1; chromatin; differentiation therapy; ACUTE MYELOID-LEUKEMIA; LINEAGE COMMITMENT; RETINOIC ACID; C/EBP-ALPHA; HISTONE DEACETYLASE; GENE-EXPRESSION; STEM-CELLS; TERMINAL DIFFERENTIATION; ERYTHROLEUKEMIA-CELLS; REGULATORY NETWORK;

D O I：

10.1038/leu.2010.104

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Hematopoiesis is coordinated by a complex regulatory network of transcription factors and among them PU.1 (Spi1, Sfpi1) represents a key molecule. This review summarizes the indispensable requirement of PU.1 during hematopoietic cell fate decisions and how the function of PU.1 can be modulated by protein-protein interactions with additional factors. The mutual negative regulation between PU.1 and GATA-1 is detailed within the context of normal and leukemogenic hematopoiesis and the concept of 'differentiation therapy' to restore normal cellular differentiation of leukemic cells is discussed. Leukemia (2010) 24, 1249-1257; doi:10.1038/leu.2010.104; published online 3 June 2010

引用

页码：1249 / 1257

页数：9

共 108 条

[91] Leukemogenesis caused by incapacitated GATA-1 function [J].

Shimizu, R ;

Kuroha, T ;

Ohneda, O ;

Pan, XQ ;

Ohneda, K ;

Takahashi, S ;

Philipsen, S ;

Yamamoto, M .

MOLECULAR AND CELLULAR BIOLOGY, 2004, 24 (24) :10814-10825

[92] Induction of hyperproliferative fetal megakaryopoiesis by an N-terminally truncated GATA1 mutant [J].

Shimizu, Ritsuko ;

Kobayashi, Eri ;

Engel, James Douglas ;

Yamamoto, Masayuki .

GENES TO CELLS, 2009, 14 (09) :1119-1131

[93] A Recurrent Network Involving the Transcription Factors PU.1 and Gfi1 Orchestrates Innate and Adaptive Immune Cell Fates [J].

Spooner, Chauncey J. ;

Cheng, Jason X. ;

Pujadas, Elisabet ;

Laslo, Peter ;

Singh, Harinder .

IMMUNITY, 2009, 31 (04) :576-586

[94] Functional cross-antagonism between transcription factors FLI-1 and EKLF [J].

Starck, J ;

Cohet, N ;

Gonnet, C ;

Sarrazin, S ;

Doubeikovskaia, Z ;

Doubeikovski, A ;

Verger, A ;

Duterque-Coquillaud, M ;

Morle, F .

MOLECULAR AND CELLULAR BIOLOGY, 2003, 23 (04) :1390-1402

[95] A distal single nucleotide polymorphism alters long-range reguiavon of the PU-1 gene in acute myeloid leukemia [J].

Steidl, Ulrich ;

Steidl, Christian ;

Ebralidze, Alexander ;

Chapuy, Bjoen ;

Han, Hye-Jung ;

Will, Britta ;

Rosenbauer, Frank ;

Becker, Annegret ;

Wagner, Katharina ;

Koschmieder, Steffen ;

Kobayashi, Susumu ;

Costa, Daniel B. ;

Schuiz, Thomas ;

O'Brien, Karen B. ;

Verhaak, Roel G. W. ;

Dawel, Ruud ;

Haase, Detlef ;

Truemper, Lorenz ;

Krauter, Juergen ;

Kohwi-ShigematSU, Terumi ;

Griesinger, Frank ;

Tenen, Daniel G. .

JOURNAL OF CLINICAL INVESTIGATION, 2007, 117 (09) :2611-2620

[96] PU.1 inhibits the erythroid program by binding to GATA-1 on DNA and creating a repressive chromatin structure [J].

Stopka, T ;

Amanatullah, DF ;

Papetti, M ;

Skoultchi, AI .

EMBO JOURNAL, 2005, 24 (21) :3712-3723

[97] Differential context-dependent effects of friend of GATA-1 (FOG-1) on mast-cell development and differentiation [J].

Sugiyama, Daijiro ;

Tanaka, Makoto ;

Kitajima, Kenji ;

Zheng, Jie ;

Yen, Hilo ;

Murotani, Tomotaka ;

Yamatodani, Atsushi ;

Nakano, Toru .

BLOOD, 2008, 111 (04) :1924-1932

[98] Failure of megakaryopoiesis and arrested erythropoiesis in mice lacking the GATA-1 transcriptional cofactor FOG [J].

Tsang, AP ;

Fujiwara, Y ;

Hom, DB ;

Orkin, SH .

GENES & DEVELOPMENT, 1998, 12 (08) :1176-1188

[99] High expression of B-cell receptor inducible gene BIC in all subtypes of Hodgkin lymphoma [J].

van den Berg, A ;

Kroesen, BJ ;

Kooistra, K ;

de Jong, D ;

Briggs, J ;

Blokzijl, T ;

Jacobs, S ;

Kluiver, J ;

Diepstra, A ;

Maggio, E ;

Poppema, S .

GENES CHROMOSOMES & CANCER, 2003, 37 (01) :20-28

[100] MicroRNA-155 regulates the generation of immunoglobulin class-switched plasma cells [J].

Vigorito, Elena ;

Perks, Kerry L. ;

Abreu-Goodger, Cei ;

Bunting, Sam ;

Xiang, Zou ;

Kohlhaas, Susan ;

Das, Partha P. ;

Miska, Eric A. ;

Rodriguez, Antony ;

Bradley, Allan ;

Smith, Kenneth G. C. ;

Rada, Cristina ;

Enright, Anton J. ;

Toellner, Kai-Michael ;

MacLennan, Ian C. M. ;

Turner, Martin .

IMMUNITY, 2007, 27 (06) :847-859

← 2 3 4 5 6 7 8 9 10 11 →