A para-amino substituent on the D-ring of green tea polyphenol epigallocatechin-3-gallate as a novel proteasome inhibitor and cancer cell apoptosis inducer

被引：49

作者：

Osanai, Kumi

Landis-Piwowar, Kristin R.

Dou, Q. Ping

Chan, Tak Hang ^{[1
]}

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synthesis, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synthesis, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[3] Wayne State Univ, Sch Med, Prevent Program, Barbana Ann Karmanos Canc Inst, Detroit, MI 48202 USA

[4] Wayne State Univ, Sch Med, Dept Pathol, Detroit, MI 48202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2007年 / 15卷 / 15期

关键词：

green tea polyphenols; epigallocatechin-3-gallate; para-aminobenzoic acid; pro-drug; proteasome; apoptosis;

D O I：

10.1016/j.bmc.2007.05.041

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Analogs of (-)-EGCG containing a para-amino group on the D-ring in place of the hydroxyl groups have been synthesized and their proteasome inhibitory activities were studied. We found that, the O-acetylated (-)-EGCG analogs possessing a p-NH2 or p-NHBoc (Boc; tert-butoxycarbonyl) D-ring (5 and 7) act as novel tumor cellular proteasome inhibitors and apoptosis inducers with potency similar to natural (-)-EGCG and similar to (-)-EGCG peracetate. These data suggest that the acetylated amino-GTP analogs have the potential to be developed into novel anticancer agents. (c) 2007 Elsevier Ltd. All rights reserved.

引用

页码：5076 / 5082

页数：7

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