Challenges facing islet transplantation for the treatment of type 1 diabetes mellitus

被引：157

作者：

Rother, KI

Harlan, DM

机构：

[1] Natl Inst Diabet, Islet & Autoimmun Branch, NIH, Bethesda, MD 20892 USA

[2] Natl Inst Digest & Kidney Dis, Islet & Autoimmun Branch, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 114卷 / 07期

关键词：

D O I：

10.1172/JC1200423235

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Islet transplantation represents a most impressive recent advance in the search for a type 1 diabetes mellitus cure. While several hundred patients have achieved at least temporary insulin independence after receiving the islet "mini-organs" (containing insulin-producing P cells), very few patients remain insulin independent beyond 4 years after transplantation. In this review, we describe historic as well as technical details about the procedure and provide insight into clinical and basic research efforts to overcome existing hurdles for this promising therapy.

引用

收藏

页码：877 / 883

页数：7

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