State of the art - sirtuin 1 in kidney pathology - clinical relevance

被引：12

作者：

Bazyluk, Angelika ^{[1
]}

Malyszko, Jolanta ^{[1
,2
]}

Hryszko, Tomasz ^{[1
]}

Zbroch, Edyta ^{[1
]}

机构：

[1] Med Univ Bialystok, Dept Nephrol & Hypertens 2, Sklodowskiej Curie 24a, PL-15276 Bialystok, Poland

[2] Warsaw Med Univ, Dept Nephrol Dialysis & Internal Med, Warsaw, Poland

来源：

ADVANCES IN MEDICAL SCIENCES | 2019年 / 64卷 / 02期

关键词：

SIRT1; Sirtuin; Kidney; Kidney pathology; DIABETIC-NEPHROPATHY; OXIDATIVE STRESS; MESENCHYMAL TRANSITION; FIBROBLAST ACTIVATION; INTERSTITIAL FIBROSIS; HISTONE DEACETYLASE; INSULIN-RESISTANCE; GENE POLYMORPHISMS; PODOCYTE FUNCTION; LIPID-METABOLISM;

D O I：

10.1016/j.advms.2019.04.005

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Sirtuins represent a group of nicotinamide adenine dinucleotide dependent histone deacetylases, which regulates various biological pathways by promoting chromatin silencing and transcriptional repression. Therefore, they are linked to cellular energy metabolism, mitochondrial biogenesis, stress response, apoptosis, inflammation and fibrosis. Since sirtuin 1 became a promising candidate for targeted therapies of numerous conditions, researchers have been investigating its activator. As for now, natural agents and antidiabetic drug - metformin, have been found to activate sirtuin 1. Sirtuin 1 is able to improve kidney outcomes by direct impact on kidney cells, regulation of non-specific processes generally involved in pathogenesis of age-dependent and metabolic disorders and improvement of the comorbid diseases. This review discusses the state of the art knowledge on the role of sirtuin 1 on kidney pathology.

引用

页码：356 / 364

页数：9

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