Cytoplasmic beta-catenin accumulation as a predictor of hematogenous metastasis in human colorectal cancer

被引：105

作者：

Maruyama, K

Ochiai, A

Akimoto, S

Nakamura, S

Baba, S

Moriya, Y

Hirohashi, S

机构：

[1] Natl Canc Ctr, Res Inst, Div Pathol, Chuo Ku, Tokyo 1040045, Japan

[2] Hamamatsu Univ Sch Med, Dept Surg 2, Hamamatsu, Shizuoka 43131, Japan

[3] Natl Canc Ctr, Div Surg, Tokyo, Japan

来源：

ONCOLOGY | 2000年 / 59卷 / 04期

关键词：

beta-catenin accumulation; colorectal adenocarcinoma; hematogenous metastasis; intratumoral heterogeneity immunohistochemistry;

D O I：

10.1159/000012187

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The membranous, cytoplasmic and nuclear levels of beta-catenin were evaluated immunohistochemically in archival tissue specimens from 96 Japanese patients with primary colorectal carcinoma who had undergone surgery. The relationships between beta-catenin and clinicopathological variables were analyzed statistically. Reduced beta-catenin immunoreactivity in the cell membranes of cancer cells was found in 70% of the tumors, and cytoplasmic and nuclear accumulation of beta-catenin were found in 68 and 66% of tumors, respectively. Significant correlations between cytoplasmic beta-catenin accumulation and the depth of invasion, venous invasion and focal dedifferentiation were observed. Cy toplasmic beta-catenin accumulation was also found to be a useful predictor of hematogenous metastasis (hazard ratio = 8.94, p = 0.054), though neither a reduced cell membrane level nor nuclear accumulation of beta-catenin correlated with metastasis, Copyright (C) 2000 S. Karger AG. Basel.

引用

页码：302 / 309

页数：8

共 38 条

[1] Expression of cadherin-catenin cell adhesion molecules, phosphorylated tyrosine residues and growth factor receptor-tyrosine kinases in gastric cancers [J].