Electrocardiographic PR Prolongation and Atrial Fibrillation Risk: A Meta-Analysis of Prospective Cohort Studies

被引：47

作者：

Cheng, Min ^{[1
,2
]}

Lu, Xiangfeng ^{[1
,2
]}

Huang, Jianfeng ^{[1
,2
]}

Zhang, Shu ^{[1
,2
]}

Gu, Dongfeng ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100730, Peoples R China

[2] Peking Union Med Coll, Beijing 100021, Peoples R China

来源：

JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY | 2015年 / 26卷 / 01期

关键词：

atrial fibrillation; AV node; epidemiology; Framingham study; PR interval; ATRIOVENTRICULAR-CONDUCTION TIME; AUTONOMIC NERVOUS-SYSTEM; GENOME-WIDE ASSOCIATION; INTERVAL; STIMULATION; PREVALENCE; OUTCOMES; STROKE; ADULTS; VAGAL;

D O I：

10.1111/jce.12539

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

PR Interval and Atrial Fibrillation BackgroundElectrocardiographic PR interval prolongation is considered a benign condition, but recent studies have challenged the notion by demonstrating that prolonged PR interval is associated with an increased risk of atrial fibrillation (AF). ObjectiveThe purpose of this study was to perform a meta-analysis of prospective cohort studies to evaluate the evidence supporting an association of prolonged PR interval with AF incidence. MethodsWe searched the MEDLINE and EMBASE database (from inception to May 2014) supplemented by manual searches of references of relevant retrieved articles. Prospective cohort studies were included with hazard ratio (HR) of prolonged PR interval for incident AF. ResultsThe search strategy yielded 6 cohort studies meeting eligibility criteria. A total of 328,932 participants were included, with 14,191 participants suffering from AF during follow-up. Pooled HRs of prolonged PR interval for incident AF was 1.30 (95% CI: 1.13 to 1.49) using random-effect model (I-2 = 30%). There was a significant difference of combined HRs between studies with and without adjustment for taking of AV nodal blocking agents in subgroup analysis. Sensitivity analysis supported the robustness of the results. ConclusionsProlonged PR interval is not a totally benign condition but an independent risk factor for AF incidence. The mechanisms underlying the association of prolonged PR interval with AF incidence need further research.

引用

页码：36 / 41

页数：6

共 31 条

[21] Genome-wide association study of PR interval [J].

Pfeufer, Arne ;

van Noord, Charlotte ;

Marciante, Kristin D. ;

Arking, Dan E. ;

Larson, Martin G. ;

Smith, Albert Vernon ;

Tarasov, Kirill V. ;

Mueller, Martina ;

Sotoodehnia, Nona ;

Sinner, Moritz F. ;

Verwoert, Germaine C. ;

Li, Man ;

Kao, W. H. Linda ;

Koettgen, Anna ;

Coresh, Josef ;

Bis, Joshua C. ;

Psaty, Bruce M. ;

Rice, Kenneth ;

Rotter, Jerome I. ;

Rivadeneira, Fernando ;

Hofman, Albert ;

Kors, Jan A. ;

Stricker, Bruno H. C. ;

Uitterlinden, Andre G. ;

van Duijn, Cornelia M. ;

Beckmann, Britt M. ;

Sauter, Wiebke ;

Gieger, Christian ;

Lubitz, Steven A. ;

Newton-Cheh, Christopher ;

Wang, Thomas J. ;

Magnani, Jared W. ;

Schnabel, Renate B. ;

Chung, Mina K. ;

Barnard, John ;

Smith, Jonathan D. ;

Van Wagoner, David R. ;

Vasan, Ramachandran S. ;

Aspelund, Thor ;

Eiriksdottir, Gudny ;

Harris, Tamara B. ;

Launer, Lenore J. ;

Najjar, Samer S. ;

Lakatta, Edward ;

Schlessinger, David ;

Uda, Manuela ;

Abecasis, Goncalo R. ;

Mueller-Myhsok, Bertram ;

Ehret, Georg B. ;

Boerwinkle, Eric .

NATURE GENETICS, 2010, 42 (02) :153-U89

[22] VAGAL ACTION ON ATRIOVENTRICULAR-CONDUCTION AND ITS INHIBITION BY SYMPATHETIC-STIMULATION AND NEUROPEPTIDE-Y IN ANESTHETIZED DOGS [J].

PIROLA, FT ;

POTTER, EK .

JOURNAL OF THE AUTONOMIC NERVOUS SYSTEM, 1990, 31 (01) :1-12

[23]

ROSE G, 1978, BRIT HEART J, V40, P636

[24] Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae [J].

Smith, J. Gustav ;

Lowe, Jennifer K. ;

Kovvali, Sirisha ;

Maller, Julian B. ;

Salit, Jacqueline ;

Daly, Mark J. ;

Stoffel, Markus ;

Altshuler, David M. ;

Friedman, Jeffrey M. ;

Breslow, Jan L. ;

Newton-Cheh, Christopher .

HEART RHYTHM, 2009, 6 (05) :634-641

[25] Explaining the inconsistent associations of PR interval with mortality: The role of P-duration contribution to the length of PR interval [J].

Soliman, Elsayed Z. ;

Cammarata, Michael ;

Li, Yabing .

HEART RHYTHM, 2014, 11 (01) :93-98

[26] Ethnic Distribution of ECG Predictors of Atrial Fibrillation and Its Impact on Understanding the Ethnic Distribution of Ischemic Stroke in the Atherosclerosis Risk in Communities (ARIC) Study [J].

Soliman, Elsayed Z. ;

Prineas, Ronald J. ;

Case, L. Douglas ;

Zhang, Zhu-ming ;

Goff, David C., Jr. .

STROKE, 2009, 40 (04) :1204-1211

[27] INFLUENCE OF BRIEF VAGAL AND STELLATE NERVE-STIMULATION ON PACEMAKER ACTIVITY AND CONDUCTION WITHIN ATRIOVENTRICULAR CONDUCTION SYSTEM OF DOG [J].

SPEAR, JF ;

MOORE, EN .

CIRCULATION RESEARCH, 1973, 32 (01) :27-41

[28] Meta-analysis of observational studies in epidemiology - A proposal for reporting [J].

Stroup, DF ;

Berlin, JA ;

Morton, SC ;

Olkin, I ;

Williamson, GD ;

Rennie, D ;

Moher, D ;

Becker, BJ ;

Sipe, TA ;

Thacker, SB .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2000, 283 (15) :2008-2012

[29] Functional NaV1.8 Channels in Intracardiac Neurons The Link Between SCN10A and Cardiac Electrophysiology [J].

Verkerk, Arie O. ;

Remme, Carol Ann ;

Schumacher, Cees A. ;

Scicluna, Brendon P. ;

Wolswinkel, Rianne ;

de Jonge, Berend ;

Bezzina, Connie R. ;

Veldkamp, Marieke W. .

CIRCULATION RESEARCH, 2012, 111 (03) :333-343

[30] ETIOLOGY OF PROLONGATION OF P-R INTERVAL IN PATIENTS WITH AN ENDOCARDIAL CUSHION DEFECT - FURTHER OBSERVATIONS ON INTERNODAL CONDUCTION AND POLARITY OF RETROGRADE-P WAVE [J].

WALDO, AL ;

KAISER, GA ;

BOWMAN, FO ;

MALM, JR .

CIRCULATION, 1973, 48 (01) :19-26

← 1 2 3 4 →