Innate and adaptive immune responses to an intracellular bacterium, Francisella tularensis live vaccine strain

被引：147

作者：

Elkins, KL ^{[1
]}

Cowley, SC ^{[1
]}

Bosio, CM ^{[1
]}

机构：

[1] US FDA, Lab Mycobacteria, Div Bacterial Parasit & Allergen Prod, Ctr Biol Evaluat & Res, Rockville, MD 20852 USA

来源：

MICROBES AND INFECTION | 2003年 / 5卷 / 02期

关键词：

Francisella tularensis; mice; T-lymphocytes; B-lymphocytes; bacterial vaccines; interferon type II; immunity; natural;

D O I：

10.1016/S1286-4579(02)00084-9

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The immune response to intracellular bacterium, Francisella tularensis, which causes tularemia and is proposed to be a potential bioterrorism pathogen, has been studied in mice using the attenuated live vaccine strain (LVS). Here we review this infection model, which provides a convenient means of studying protective immune mechanisms not only for Francisella, but also for the large and important class of intracellular pathogens. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.

引用

页码：135 / 142

页数：8

共 44 条

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