Milk exosomes: Nature's abundant nanoplatform for theranostic applications

被引：140

作者：

Adriano, Benilde ^{[1
,2
]}

Cotto, Nycol M. ^{[1
,2
]}

Chauhan, Neeraj ^{[1
,2
]}

Jaggi, Meena ^{[1
,2
]}

Chauhan, Subhash C. ^{[1
,2
]}

Yallapu, Murali M. ^{[1
,2
]}

机构：

[1] Univ Texas Rio Grande Valley, Sch Med, Dept Immunol & Microbiol, Mcallen, TX 78504 USA

[2] Univ Texas Rio Grande Valley, South Texas Ctr Excellence Canc Res, Sch Med, Mcallen, TX 78504 USA

来源：

BIOACTIVE MATERIALS | 2021年 / 6卷 / 08期

关键词：

Milk exosomes; Extracellular vesicles; Drug delivery; Imaging agents; Theranostic applications; DRUG-DELIVERY SYSTEM; EXTRACELLULAR VESICLES; ENGINEERING EXOSOMES; CANCER; CURCUMIN; BOVINE; CELLS; NANOFORMULATIONS; NANOMEDICINE; DOXORUBICIN;

D O I：

10.1016/j.bioactmat.2021.01.009

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Exosomes are a unique subpopulation of naturally occurring extracellular vesicles which are smaller intracellular membrane nanoparticle vesicles. Exosomes have proven to be excellent nanocarriers for carrying lipids, proteins, mRNAs, non-coding RNAs, and DNAs, and disseminating long-distance intercellular communications in various biological processes. Among various cell-line or biological fluid derived exosomes, milk exosomes are abundant in nature and exhibit many nanocarrier characteristics favorable for theranostic applications. To be an effective delivery carrier for their clinical translation, exosomes must inbuilt loading, release, targeting, and imaging/tracking characteristics. Considering the unmet gaps of milk exosomes in theranostic technology it is essential to focus the current review on drug delivery and imaging applications. This review delineates the efficiency of exosomes to load therapeutic or imaging agents and their successful delivery approaches. It is emphasized on possible modifications of exosomes towards increasing the stability and delivery of agents. This article also summarizes the specific applications and the process of developing milk exosomes as a future pharmaceutical drug delivery vehicle.

引用

页码：2479 / 2490

页数：12

共 106 条

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Natural ligand-receptor mediated loading of siRNA in milk derived exosomes [J].