Inflammation and oncogenesis: a vicious connection

被引：344

作者：

Grivennikov, Sergei I.

Karin, Michael ^{[1
]}

机构：

[1] Univ Calif San Diego, Sch Med, Dept Pharmacol, Lab Gene Regulat & Signal Transduct, La Jolla, CA 92093 USA

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 01期

基金：

美国国家卫生研究院;

关键词：

NF-KAPPA-B; CANCER-RELATED INFLAMMATION; EPITHELIAL-MESENCHYMAL TRANSITION; COLITIS-ASSOCIATED CANCER; IMMUNE CELLS; TUMOR ANGIOGENESIS; MYELOID CELLS; T-CELLS; SUPPRESSOR-CELLS; MOUSE MODEL;

D O I：

10.1016/j.gde.2009.11.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Epidemiological and experimental data suggest a close connection between inflammation and tumorigenesis. Solid tumors are typically infiltrated with immune cells and inflammation impacts most, if not all, stages of tumorigenesis. Molecular and cellular pathways, which connect inflammation and cancer, have emerged as attractive targets for prevention and therapy. In this review we discuss general mechanisms and concepts of cancer promoting inflammation.

引用

页码：65 / 71

页数：7

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