Programmed cell death regulation: basic mechanisms and therapeutic opportunities

被引：30

作者：

Johnson, DE

机构：

[1] Univ Pittsburgh, Dept Med, Div Hematol Oncol, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Pharmacol, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Ctr Canc, Pittsburgh, PA USA

来源：

LEUKEMIA | 2000年 / 14卷 / 08期

关键词：

apoptosis; mitochondria; Bcl-2; caspase; IAP; TRAIL;

D O I：

10.1038/sj.leu.2401849

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The molecular mechanisms responsible for induction or inhibition of apoptosis signal transduction have been intensively investigated during the past few years. Information gained from mechanistic studies and from structural analysis of apoptosis regulatory proteins has provided considerable insight into the pathways that determine whether a cell will live or die. Many of these advances were recently presented at the American Association for Cancer Research Special Conference on 'Programmed Cell Death Regulation: Basic Mechanisms and Therapeutic Opportunities'. This mini-review will discuss the current state of knowledge regarding apoptosis signaling pathways and the function of apoptosis regulatory proteins.

引用

收藏

页码：1340 / 1344

页数：5

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