Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology

被引：69

作者：

Credito, Kim ^{[1
]}

Lin, Gengrong ^{[1
]}

Appelbaum, Peter C. ^{[1
]}

机构：

[1] Hershey Med Ctr, Dept Pathol, Hershey, PA 17033 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2007年 / 51卷 / 04期

关键词：

D O I：

10.1128/AAC.01455-06

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The synergistic effects of daptomycin plus gentamicin or rifampin were tested against 50 Staphylococcus aureus strains, with daptomycin MICs ranging between 0.25 and 8 mu g/ml. Daptomycin sub-MICs combined with gentamicin concentrations lower than the MIC yielded synergy in 34 (68%) of the 50 strains. Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin.

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页码：1504 / 1507

页数：4

相关论文

共 25 条

[1]

ADERN PV, 2005, NEW ENGL J MED, V353, P1245

[2] Activities of clinafloxacin, alone and in combination with other compounds, against 45 gram-positive and -negative organisms for which clinafloxacin MICs are high [J].

Clark, CL ;

Jacobs, MR ;

Appelbaum, PC .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1999, 43 (09) :2295-2298

[3] Correlation between reduced daptomycin susceptibility and vancomycin resistance in vancomycin-intermediate Staphylococcus aureus [J].

Cui, LZ ;

Tominaga, E ;

Neoh, HM ;

Hiramatsu, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (03) :1079-1082

[4] Novel mechanism of antibiotic resistance originating in vancomycin-intermediate Staphylococcus aureus [J].

Cui, LZ ;

Iwamoto, A ;

Lian, JQ ;

Neoh, HM ;

Maruyama, T ;

Horikawa, Y ;

Hiramatsu, K .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (02) :428-438

[5]

DELASSENCE A, CLIN INFECT DIS, V42, P170

[6] Pharmacokinetics of gentamicin at traditional versus high doses: Implications for once-daily aminoglycoside dosing [J].

Demczar, DJ ;

Nafziger, AN ;

Bertino, JS .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1997, 41 (05) :1115-1119

[7] Polyclonal emergence and importation of community-acquired methicillin-resistant Staphylococcus aureus strains harbouring Panton-Valentine leucocidin genes in Belgium [J].

Denis, O ;

Deplano, A ;

De Beenhouwer, H ;

Hallin, M ;

Huysmans, G ;

Garrino, MG ;

Glupczynski, Y ;

Malaviolle, X ;

Vergison, A ;

Struelens, MJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (06) :1103-1106

[8] Methicillin-resistant Staphylococcus aureus:: An evolutionary, epidemiologic, and therapeutic odyssey [J].

Deresinski, S .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (04) :562-573

[9] Serum bactericidal activities of high-dose daptomycin with and without coadministration of gentamicin against isolates of Staphylococcus aureus and Enterococcus species [J].

DeRyke, C. Andrew ;

Sutherland, Christina ;

Zhang, Bo ;

Nicolau, David P. ;

Kuti, Joseph L. .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2006, 50 (11) :3529-3534

[10] Severe community-onset pneumonia in healthy adults caused by methicillin-resistant Staphylococcus aureus carrying the Panton-Valentine leukocidin genes [J].

Francis, JS ;

Doherty, MC ;

Lopatin, U ;

Johnston, CP ;

Sinha, G ;

Ross, T ;

Cai, M ;

Hansel, NN ;

Perl, T ;

Ticehurst, JR ;

Carroll, K ;

Thomas, DL ;

Nuermberger, E ;

Bartlett, JG .

CLINICAL INFECTIOUS DISEASES, 2005, 40 (01) :100-107