Synthesis and preliminary biological evaluation of 6-O-[11C]-[(methoxymethyl)benzyllguanines, new potential PET breast cancer imaging agents for the DNA repair protein AGT

被引：17

作者：

Liu, X

Zheng, QH ^{[1
]}

Fei, XS

Wang, JQ

Ohannesian, DW

Erickson, LC

Stone, KL

Hutchins, GD

机构：

[1] Indiana Univ, Sch Med, Dept Radiol, Indianapolis, IN 46202 USA

[2] Indiana Univ, Sch Med, Dept Pharmacol & Toxicol, Indianapolis, IN 46202 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(02)01048-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Novel radiolabeled O-6-benzylguanine derivatives, 6-O-[C-11]-[(methoxymethyl)benzyl]guanines ([C-11]p-O-MMBG. 1a: [C-11]m-O-6-MMBG. 1b: ([C-11]m-O-6-MMBG. 1c), have been synthesized for evaluation as new potential positron emission tomograph (PET) breast cancer imaging agents for DNA repair protein. O-6-alkylguanine-DNA alkyltransferase (AGT). (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：641 / 644

页数：4

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