Gadolinium(III)-incorporated nanosized mesoporous silica as potential magnetic resonance imaging contrast agents

被引：118

作者：

Lin, YS

Hung, Y

Su, JK

Lee, R

Chang, C

Lin, ML

Mou, CY ^{[1
]}

机构：

[1] Natl Taiwan Univ, Dept Chem, Taipei 106, Taiwan

[2] Natl Taiwan Univ, Ctr Condensed Matter Sci, Taipei 106, Taiwan

[3] Acad Sinica, Inst Biomed Sci, Taipei 115, Taiwan

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2004年 / 108卷 / 40期

关键词：

D O I：

10.1021/jp047829a

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new class of potential magnetic resonance imaging contrast agents with nanosized mesoporous silica as the metal carrier is reported. Gadolinium-incorporated mesoporous silicas were synthesized by using longchain surfactant as a template. The products were characterized with X-ray powder diffraction, nitrogen adsorption-desorption isotherms, high-resolution transmission electron microscopy, X-ray photoelectron spectroscopy, Si-29-MAS NMR, and proton relaxivity. The materials showed much higher relaxivities, r(1) and r(2), than Gd-DTPA. The particles are nanosized and can enter cells easily. This is a completely novel biomedical application of mesoporous silica materials.

引用

页码：15608 / 15611

页数：4

共 22 条

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