Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin A

被引：44

作者：

Ackerson, B ^{[1
]}

Rey, O ^{[1
]}

Canon, J ^{[1
]}

Krogstad, P ^{[1
]}

机构：

[1] UNIV CALIF LOS ANGELES, DEPT PEDIAT, DIV PEDIAT INFECT DIS, LOS ANGELES, CA 90095 USA

来源：

JOURNAL OF VIROLOGY | 1998年 / 72卷 / 01期

关键词：

D O I：

10.1128/JVI.72.1.303-308.1998

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Gag polyprotein-mediated incorporation of cellular cyclophilin A (CyPA) into virions is essential for the formation of infectious human immunodeficiency virus type 1 (HIV-1) virions. Either a point mutation in Gag (P222A) or drugs which bind CyPA decrease virion incorporation of CyPA and interfere with HIV-1 replication. We have found that lymphoid cells varied greatly in their CyPA content and that cells with high CyPA content supported the replication of P222A HIV-1 Gag mutants. These experiments demonstrated that a higher cellular CyPA content of some cells was able to compensate for the decreased binding affinity of P222A mutant Gag for CyPA, allowing virus replication to occur.

引用

页码：303 / 308

页数：6

共 42 条

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