Cells with high cyclophilin A content support replication of human immunodeficiency virus type 1 Gag mutants with decreased ability to incorporate cyclophilin A

被引:44
作者
Ackerson, B [1 ]
Rey, O [1 ]
Canon, J [1 ]
Krogstad, P [1 ]
机构
[1] UNIV CALIF LOS ANGELES, DEPT PEDIAT, DIV PEDIAT INFECT DIS, LOS ANGELES, CA 90095 USA
关键词
D O I
10.1128/JVI.72.1.303-308.1998
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Gag polyprotein-mediated incorporation of cellular cyclophilin A (CyPA) into virions is essential for the formation of infectious human immunodeficiency virus type 1 (HIV-1) virions. Either a point mutation in Gag (P222A) or drugs which bind CyPA decrease virion incorporation of CyPA and interfere with HIV-1 replication. We have found that lymphoid cells varied greatly in their CyPA content and that cells with high CyPA content supported the replication of P222A HIV-1 Gag mutants. These experiments demonstrated that a higher cellular CyPA content of some cells was able to compensate for the decreased binding affinity of P222A mutant Gag for CyPA, allowing virus replication to occur.
引用
收藏
页码:303 / 308
页数:6
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