Autoimmune thrombocytopenia: A complication of fludarabine therapy in lymphoproliferative disorders

被引:30
作者
Leach, M
Parsons, RM
Reilly, JT
Winfield, DA
机构
[1] Stobhill Gen Hosp, Dept Haematol, Glasgow G20 3UW, Lanark, Scotland
[2] Ninewells Hosp, Dept Pharm, Dundee DD1 9SY, Scotland
[3] Royal Hallamshire Hosp, Dept Haematol, Sheffield S10 2JF, S Yorkshire, England
来源
CLINICAL AND LABORATORY HAEMATOLOGY | 2000年 / 22卷 / 03期
关键词
autoimmune thrombocytopenia; fludarbine; lymphoproliferative disorders;
D O I
10.1046/j.1365-2257.2000.00305.x
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We describe two cases of autoimmune thrombocytopenia precipitated by fludarabine therapy in patients with chronic lymphatic leukaemia. Both were treated with high dose steroids and initially responded with recovery of normal platelet counts. One patient developed recurrent autoimmune thrombocytopenia on two occasions following re-exposure to the drug when his disease had become refractory to all other treatments. A retrospective review of the case notes of 45 patients with lymphoproliferative disorders treated with fludarabine over the past 6 years indicated the development of autoimmune thrombocytopenia in 4.5% (two out of 45) and autoimmune haemolytic anaemia in 6.7% (three of the 45).
引用
收藏
页码:175 / 178
页数:4
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