Does propofol reduce vomiting after strabismus surgery in children?

Background: Previous studies have indicated that propofol anaesthesia may reduce the incidence of postoperative nausea and vomiting after strabismus surgery in children. This study was designed to investigate the incidence of vomiting after strabismus surgery at two different levels of propofol anaesthesia compared to thiopental/isoflurane anaesthesia. Methods: Ninety ASA class I or II children, aged 5-14 yrs were randomly assigned to one of three groups: Group T/I (n=30) induction with 5 mg kg(-1) of thiopental and maintenance with isoflurane, group P5 (n=31) induction with propofol 2 mg kg(-1) maintenance with propofol infusion 5 mg kg(-1) h(-1) or group P10 (n=29) induction with propofol 2 mg kg(-1), maintenance with propofol 10 mg kg(-1) h(-1). All received glycopyrrolate, vecuronium, fentanyl and controlled ventilation with O-2/N2O 30/70. Ketorolac i.v. , was given to prevent postoperative pain. If additional analgesia was needed, ibuprofen/acetaminophen or buprenorphine was given according to clinical need. Results: There were no differences between study groups with respect to age, weight, history of previous anaesthesia or emesis after previous anaesthesia, duration of anaesthesia, surgery or sleep after anaesthesia, or number of muscles operated. The incidence of vomiting was 37%, 29% and 28% in groups T/I, P5 and P10, respectively There were no statistically significant differences between the three groups in the incidence of vomiting. The median age of patients who vomited was 7.5 (range 5.0-13.7) yrs while the median age of the patients who did not vomit was 9.1 (range 5.0-14.0) yrs (P<0.01). Conclusion: In the present study, propofol anaesthesia compared to thiopental/isoflurane anaesthesia did not reduce the incidence of vomiting following strabismus surgery in children.