PTEN enters the nuclear age

被引：152

作者：

Baker, Suzanne J. ^{[1
]}

机构：

[1] St Jude Childrens Hosp, Dept Dev Neurobiol, Memphis, TN 38105 USA

来源：

CELL | 2007年 / 128卷 / 01期

关键词：

D O I：

10.1016/j.cell.2006.12.023

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Regulation of the PTEN tumor suppressor protein is poorly understood. In this issue, Wang et al. (2007) and Trotman et al. (2007) describe how ubiquitination regulates PTEN stability and its nuclear localization. Additionally, Shen et al. (2007) report that a nuclear pool of PTEN helps to maintain chromosomal stability.

引用

页码：25 / 28

页数：4

共 16 条

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