Cyclocondensation reaction of 4-aryl-4-methoxy-1,1,1-trifluoro-3-buten-2-ones with urea Synthesis of novel 6-aryl(5-methyl)-4-trifluoromethyl-2(1H)-pyrimidinones

被引：43

作者：

Bonacorso, HG ^{[1
]}

Lopes, IS ^{[1
]}

Wastowski, AD ^{[1
]}

Zanatta, N ^{[1
]}

Martins, MAP ^{[1
]}

机构：

[1] Univ Fed Santa Maria, Dept Quim, NUQUIMHE, BR-97105900 Santa Maria, RS, Brazil

来源：

JOURNAL OF FLUORINE CHEMISTRY | 2003年 / 120卷 / 01期

关键词：

2(1H)-pyrimidinones; pyrimidines; enones; cyclization;

D O I：

10.1016/S0022-1139(02)00287-7

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The synthesis of a novel series of eleven 6-aryl(5-methyl)-4-trifluoromethyl-2(1H)-pyrimidinones, where aryl = Ph, 4-CH3Ph, 4-FPh, 4-ClPh, 4-BrPh, 4-OCH3Ph and alkyl = H, CH3, from the reaction of 4-aryl-4-methoxy-1,1,1-trifluoro-3-buten-2-ones with urea in the presence of hydrochloric acid, is reported. Trifluoroacetylation of acetophenone- and propiophenone-dimethylacetals derived from phenones, was employed to obtain the precursors. (C) 2002 Elsevier Science B.V. All rights reserved.

引用

页码：29 / 32

页数：4

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