Regulatory mechanisms of calcium sensitization of contractile elements in smooth muscle

被引：37

作者：

Hori, M ^{[1
]}

Karaki, H ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Pharmacol, Bunkyo Ku, Tokyo 113, Japan

来源：

LIFE SCIENCES | 1998年 / 62卷 / 17-18期

关键词：

Ca2+ sensitivity; smooth muscle; calmodulin; phosphatase; thin filament regulation;

D O I：

10.1016/S0024-3205(98)00119-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It is evident that smooth muscle contraction is regulated not only by the Ca2+/calmodulin/myosin light chain kinase system but also by modulation of Ca2+ sensitivity. Changes in free calmodulin concentrations, myosin light chain phosphorylation elicited by rho/rho-kinase, regulation of myosin phosphatase activity and thin filament-linked mechanisms are the possible mechanisms for regulation of Ca2+ sensitivity.

引用

页码：1629 / 1633

页数：5

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