Regulatory mechanisms of calcium sensitization of contractile elements in smooth muscle

被引：37

作者：

Hori, M ^{[1
]}

Karaki, H ^{[1
]}

机构：

[1] Univ Tokyo, Grad Sch Agr & Life Sci, Dept Vet Pharmacol, Bunkyo Ku, Tokyo 113, Japan

来源：

LIFE SCIENCES | 1998年 / 62卷 / 17-18期

关键词：

Ca2+ sensitivity; smooth muscle; calmodulin; phosphatase; thin filament regulation;

D O I：

10.1016/S0024-3205(98)00119-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

It is evident that smooth muscle contraction is regulated not only by the Ca2+/calmodulin/myosin light chain kinase system but also by modulation of Ca2+ sensitivity. Changes in free calmodulin concentrations, myosin light chain phosphorylation elicited by rho/rho-kinase, regulation of myosin phosphatase activity and thin filament-linked mechanisms are the possible mechanisms for regulation of Ca2+ sensitivity.

引用

页码：1629 / 1633

页数：5

共 43 条

[31] PHOSPHORYLATION OF CALDESMON BY MITOGEN-ACTIVATED PROTEIN-KINASE WITH NO EFFECT ON CA2+ SENSITIVITY IN RABBIT SMOOTH-MUSCLE [J].

NIXON, GF ;

IIZUKA, K ;

HAYSTEAD, CMM ;

HAYSTEAD, TAJ ;

SOMLYO, AP ;

SOMLYO, AV .

JOURNAL OF PHYSIOLOGY-LONDON, 1995, 487 (02) :283-289

[32] CALDESMON AND A 20-KDA ACTIN-BINDING FRAGMENT OF CALDESMON INHIBIT TENSION DEVELOPMENT IN SKINNED GIZZARD MUSCLE-FIBER BUNDLES [J].

PFITZER, G ;

ZEUGNER, C ;

TROSCHKA, M ;

CHALOVICH, JM .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :5904-5908

[33]

POHL J, 1994, BIOPHYS J, V66, pA198

[34]

SATO K, 1992, J PHARMACOL EXP THER, V261, P497

[35]

SHIMIZU H, 1994, J BIOL CHEM, V269, P30407

[36]

SHIRINSKY VP, 1992, J BIOL CHEM, V267, P15886

[37]

SINGER HA, 1987, J PHARMACOL EXP THER, V243, P814

[38]

SMITH CWJ, 1987, J BIOL CHEM, V262, P116

[39] SIGNAL-TRANSDUCTION AND REGULATION IN SMOOTH-MUSCLE [J].

SOMLYO, AP ;

SOMLYO, AV .

NATURE, 1994, 372 (6503) :231-236

[40]

Takayama M, 1996, N-S ARCH PHARMACOL, V354, P120

← 1 2 3 4 5 →