Antibodies against glycosylated native MOG are elevated in patients with multiple sclerosis

被引：60

作者：

Gaertner, S ^{[1
]}

de Graaf, KL ^{[1
]}

Greve, B ^{[1
]}

Weissert, R ^{[1
]}

机构：

[1] Univ Tubingen, Hertie Inst Clin Brain Res, Dept Gen Neurol, Expt Neuroimmunol Lab, D-72076 Tubingen, Germany

来源：

NEUROLOGY | 2004年 / 63卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000147259.34163.33

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Antibodies against native glycosylated myelin-oligodendrocyte-glycoprotein (MOG) were measured by ELISA in patients with multiple sclerosis (MS) and controls. Anti-MOG IgM antibodies were elevated during the first demyelinating event. Higher MOG-specific IgG antibodies were found in patients during relapses and in secondary chronic progressive MS compared to patients in remission and healthy controls. Antibodies against native MOG may be a potential biomarker for MS.

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页码：2381 / 2383

页数：3

相关论文

共 10 条

[1] Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event [J].

Berger, T ;

Rubner, P ;

Schautzer, F ;

Egg, R ;

Ulmer, H ;

Mayringer, I ;

Dilitz, E ;

Deisenhammer, F ;

Reindl, M .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (02) :139-145

[2] Selective unresponsiveness to conformational B cell epitopes of the myelin oligodendrocyte glycoprotein in H-2b mice [J].

Bourquin, C ;

Schubart, A ;

Tobollik, S ;

Mather, I ;

Ogg, S ;

Liblau, R ;

Linington, C .

JOURNAL OF IMMUNOLOGY, 2003, 171 (01) :455-461

[3] Structural insights into the antigenicity of myelin oligodendrocyte glycoprotein [J].

Breithaupt, C ;

Schubart, A ;

Zander, H ;

Skerra, A ;

Huber, R ;

Linington, C ;

Jacob, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9446-9451

[4] The crystal structure of myelin oligodendrocyte glycoprotein, a key autoantigen in multiple sclerosis [J].

Clements, CS ;

Reid, HH ;

Beddoe, T ;

Tynan, FE ;

Perugini, MA ;

Johns, TG ;

Bernard, CCA ;

Rossjohn, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (19) :11059-11064

[5] Immunoglobulin isotypes reveal a predominant role of type 1 immunity in multiple sclerosis [J].

Greve, B ;

Magnusson, CGM ;

Melms, A ;

Weissert, R .

JOURNAL OF NEUROIMMUNOLOGY, 2001, 121 (1-2) :120-125

[6] Similar low frequency of anti-MOG IgG and IgM in MS patients and healthy subjects [J].

Lampasona, V ;

Franciotta, D ;

Furlan, R ;

Zanaboni, S ;

Fazio, R ;

Bonifacio, E ;

Comi, G ;

Martino, G .

NEUROLOGY, 2004, 62 (11) :2092-2094

[7] ANTIBODY-RESPONSES IN CHRONIC RELAPSING EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS - CORRELATION OF SERUM DEMYELINATING ACTIVITY WITH ANTIBODY TITER TO THE MYELIN OLIGODENDROCYTE GLYCOPROTEIN (MOG) [J].

LININGTON, C ;

LASSMANN, H .

JOURNAL OF NEUROIMMUNOLOGY, 1987, 17 (01) :61-69

[8] A NOVEL MYELIN-ASSOCIATED GLYCOPROTEIN DEFINED BY A MOUSE MONOCLONAL-ANTIBODY [J].

LINNINGTON, C ;

WEBB, M ;

WOODHAMS, PL .

JOURNAL OF NEUROIMMUNOLOGY, 1984, 6 (06) :387-396

[9] Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the Diagnosis of Multiple Sclerosis [J].

McDonald, WI ;

Compston, A ;

Edan, G ;

Goodkin, D ;

Hartung, HP ;

Lublin, FD ;

McFarland, HF ;

Paty, DW ;

Polman, CH ;

Reingold, SC ;

Sandberg-Wollheim, M ;

Sibley, W ;

Thompson, AJ ;

van den Noort, S ;

Weinshenker, BY ;

Wolinsky, JS .

ANNALS OF NEUROLOGY, 2001, 50 (01) :121-127

[10] Anti-myelin oligodendrocyte glycoprotein antibodies in multiple sclerosis [J].

Reder, AT ;

Oger, JJ .

NEUROLOGY, 2004, 62 (11) :1922-1923