Testosterone exposure, dopaminergic reward, and sensation-seeking in young men

被引：74

作者：

Campbell, Benjamin C. ^{[1
]}

Dreber, Anna ^{[2
]}

Apicella, Coren L. ^{[3
]}

Eisenberg, Dan T. A. ^{[4
]}

Gray, Peter B. ^{[5
]}

Little, Anthony C. ^{[6
]}

Garcia, Justin R. ^{[7
,8
]}

Zamore, Richard S. ^{[7
,8
]}

Lum, J. Koji ^{[7
,8
]}

机构：

[1] Univ Wisconsin, Dept Anthropol, Milwaukee, WI 53211 USA

[2] Harvard Univ, Kennedy Sch, Women & Publ Policy Program, Cambridge, MA 02138 USA

[3] Harvard Univ, Dept Anthropol, Cambridge, MA 02138 USA

[4] Northwestern Univ, Dept Anthropol, Evanston, IL 60208 USA

[5] Dept Anthropol, Las Vegas, NV USA

[6] Univ Stirling, Dept Psychol, Stirling FK9 4LA, Scotland

[7] SUNY Binghamton, Dept Anthropol, Lab Evolutionary Anthropol & Hlth, Binghamton, NY 13902 USA

[8] SUNY Binghamton, Dept Biol Sci, Lab Evolutionary Anthropol & Hlth, Binghamton, NY 13902 USA

来源：

PHYSIOLOGY & BEHAVIOR | 2010年 / 99卷 / 04期

基金：

美国国家科学基金会;

关键词：

Testosterone; Sensation-seeking; DRD4; Dopaminergic reward system; DEFICIT HYPERACTIVITY DISORDER; 4TH DIGIT RATIO; MALE FACIAL ATTRACTIVENESS; SEXUAL-DIMORPHISM; DRD4; GENE; SALIVARY TESTOSTERONE; PERSONALITY-TRAITS; 7-REPEAT ALLELE; NOVELTY SEEKING; CRITICAL PERIOD;

D O I：

10.1016/j.physbeh.2009.12.011

中图分类号：

B84 [心理学];

学科分类号：

04 ; 0402 ;

摘要：

To test the relationship between androgen exposure, dopaminergic reward and sensation-seeking, we compared variation in salivary testosterone (T), 2D:4D digit ratio, facial masculinity, Zuckerman's sensation-seeking scale (SSS) and the D4 dopamine receptor (DRD4) genes from 98 young men, between the ages of 18 and 23 years. In univariate analyses, both salivary T and facial masculinity were significantly correlated with the SSS boredom susceptibility subscale, while the presence of the 7-repeat allele (7R+) in the dopamine receptor D4 gene was associated with the SSS thrill and adventure-seeking and overall sensation-seeking. Neither left nor right 2D:4D digit ratio was associated with any sensation-seeking scale. In multivariate models, salivary T and facial masculinity were significant predictors of SSS boredom susceptibility, while 7R+ was a significant predictor of SSS thrill and adventure-seeking. For overall SSS, both 7R+ and salivary T were significant predictors. There was no significant interaction of 7R+ and androgen exposure for SSS or any of the SSS subscales. These results add to earlier reports of an association between I and sensation-seeking. In addition, our results also indicate that genetic variation in DRD4 is independently associated with SSS sensation-seeking. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：451 / 456

页数：6

共 63 条

[11] SALIVA TESTOSTERONE AND CRIMINAL VIOLENCE IN YOUNG-ADULT PRISON-INMATES [J].

DABBS, JM ;

FRADY, RL ;

CARR, TS ;

BESCH, NF .

PSYCHOSOMATIC MEDICINE, 1987, 49 (02) :174-182

[12]

De la Garza R, 2000, SYNAPSE, V37, P232, DOI 10.1002/1098-2396(20000901)37:3<232::AID-SYN7>3.0.CO

[13]

2-7

[14]

DIATZMAN R, 1980, PERS INDIV DIF, V1, P103

[15] The 7R polymorphism in the dopamine receptor D4 gene (DRD4) is associated with financial risk taking in men [J].

Dreber, Anna ;

Apicella, Coren L. ;

Eisenberg, Dan T. A. ;

Garcia, Justin R. ;

Zamore, Richard S. ;

Lum, J. Koji ;

Campbell, Benjamin .

EVOLUTION AND HUMAN BEHAVIOR, 2009, 30 (02) :85-92

[16] Examining impulsivity as an endophenotype using a behavioral approach:: a DRD2 TaqI A and DRD4 48-bp VNTR association study [J].

Eisenberg, Dan T. A. ;

MacKillop, James ;

Modi, Meera ;

Beauchemin, Joshua ;

Dang, David ;

Lisman, Stephen A. ;

Lum, J. Koji ;

Wilson, David S. .

BEHAVIORAL AND BRAIN FUNCTIONS, 2007, 3 (1)

[17] Season of Birth and Dopamine Receptor Gene Associations with Impulsivity, Sensation Seeking and Reproductive Behaviors [J].

Eisenberg, Dan T. A. ;

Campbell, Benjamin ;

MacKillop, James ;

Lum, J. Koji ;

Wilson, David S. .

PLOS ONE, 2007, 2 (11)

[18]

Feigelson HS, 2001, CANCER EPIDEM BIOMAR, V10, P1005

[19] Drd4 gene polymorphisms are associated with personality variation in a passerine bird [J].

Fidler, Andrew E. ;

van Oers, Kees ;

Drent, Piet J. ;

Kuhn, Sylvia ;

Mueller, Jakob C. ;

Kempenaers, Bart .

PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2007, 274 (1619) :1685-1691

[20] Second to fourth digit ratio and sensation seeking [J].

Fink, Bernhard ;

Neave, Nick ;

Laughton, Katharine ;

Manning, John T. .

PERSONALITY AND INDIVIDUAL DIFFERENCES, 2006, 41 (07) :1253-1262

← 1 2 3 4 5 6 7 →