CD1 and CD1-restricted T cells in infections with intracellular bacteria

被引：28

作者：

Schaible, UE ^{[1
]}

Kaufmann, SHE ^{[1
]}

机构：

[1] Max Planck Inst Infect Biol, D-10117 Berlin, Germany

来源：

TRENDS IN MICROBIOLOGY | 2000年 / 8卷 / 09期

关键词：

D O I：

10.1016/S0966-842X(00)01829-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Glycolipid-specific, CD1a-, b- and c-dependent cytotoxic T cells have recently been shown to be involved in the host response against tuberculosis. These CD1 molecules 'sample' mycobacterial glycolipids from different intracellular sites in the infected cell. Additionally, upon microbial encounter, CD1d-dependent natural killer T cells promptly produce cytokines and perform regulatory activities. Here, we discuss the intracellular localization of CD1 molecules and mycobacterial lipids and the role of CD1-mediated T-cell responses in mycobacterial infections.

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页码：419 / 425

页数：7

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