Policing pregnancy: Tregs help keep the peace

被引：22

作者：

Mellor, AL ^{[1
]}

Munn, D

机构：

[1] Med Coll Georgia, Dept Med, Inst Mol Med & Genet, Program Mol Immunol, Augusta, GA 30912 USA

[2] Med Coll Georgia, Dept Pediat, Inst Mol Med & Genet, Program Mol Immunol, Augusta, GA 30912 USA

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 11期

关键词：

D O I：

10.1016/j.it.2004.09.001

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Effector T cells must be kept under control to suppress autoimmunity and immunity to innocuous antigens encountered at mucosal surfaces. In mice, T cells with regulatory functions are potent suppressors of T-cell responses and can protect tissues from T-cell-mediated destruction. The aim of this research focus is to summarize recent reports suggesting that regulatory T cells (Tregs) might be key components that protect mammalian fetuses from potentially lethal maternal adaptive immunity. Hence, defective generation or function of Tregs might explain some cases of human pregnancy failure.

引用

页码：563 / 565

页数：3

共 24 条

[1] Regulatory T cells mediate maternal tolerance to the fetus [J].

Aluvihare, VR ;

Kallikourdis, M ;

Betz, AG .

NATURE IMMUNOLOGY, 2004, 5 (03) :266-271

[2] CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].

Belkaid, Y ;

Piccirillo, CA ;

Mendez, S ;

Shevach, EM ;

Sacks, DL .

NATURE, 2002, 420 (6915) :502-507

[3] Natural versus adaptive regulatory T cells [J].

Bluestone, JA ;

Abbas, AK .

NATURE REVIEWS IMMUNOLOGY, 2003, 3 (03) :253-257

[4] Modulation of tryptophan catabolism by regulatory T cells [J].

Fallarino, F ;

Grohmann, U ;

Hwang, KW ;

Orabona, C ;

Vacca, C ;

Bianchi, R ;

Belladonna, ML ;

Fioretti, MC ;

Alegre, ML ;

Puccetti, P .

NATURE IMMUNOLOGY, 2003, 4 (12) :1206-1212

[5] CTLA-4-Ig regulates tryptophan catabolism in vivo [J].

Grohmann, U ;

Orabona, C ;

Fallarino, F ;

Vacca, C ;

Calcinaro, F ;

Falorni, A ;

Candeloro, P ;

Belladonna, ML ;

Bianchi, R ;

Fioretti, MC ;

Puccetti, P .

NATURE IMMUNOLOGY, 2002, 3 (11) :1097-1101

[6] Tolerance, DCs and tryptophan: much ado about IDO [J].

Grohmann, U ;

Fallarino, F ;

Puccetti, P .

TRENDS IN IMMUNOLOGY, 2003, 24 (05) :242-248

[7] Phenotypic characterization of regulatory T cells in the human decidua [J].

Heikkinen, J ;

Möttönen, M ;

Alanen, A ;

Lassila, O .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2004, 136 (02) :373-378

[8]

MEDAWAR PB, 1953, SYM SOC EXP BIOL, V7, P320

[9] Prevention of T cell-driven complement activation and inflammation by tryptophan catabolism during pregnancy [J].

Mellor, AL ;

Sivakumar, J ;

Chandler, P ;

Smith, K ;

Molina, H ;

Mao, DL ;

Munn, DH .

NATURE IMMUNOLOGY, 2001, 2 (01) :64-68

[10] Tryptophan catabolism and regulation of adaptive immunity [J].

Mellor, AL ;

Munn, DH .

JOURNAL OF IMMUNOLOGY, 2003, 170 (12) :5809-5813

← 1 2 3 →