Regulation of Na/Pi transporter in the proximal tubule

被引：114

作者：

Murer, H ^{[1
]}

Hernando, N ^{[1
]}

Forster, I ^{[1
]}

Biber, J ^{[1
]}

机构：

[1] Univ Zurich, Inst Physiol, CH-8057 Zurich, Switzerland

来源：

ANNUAL REVIEW OF PHYSIOLOGY | 2003年 / 65卷

关键词：

kidney; Na/Pi-cotransport; protein interactions; PDZ proteins; reabsorption; inorganic phosphate;

D O I：

10.1146/annurev.physiol.65.042902.092424

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The physiological tuning and pathophysiological alterations of renal proximal reabsorption of inorganic phosphate can be ascribed to the net amount of the Na/Pi-cotransporter NaPi-IIa localized in the brush border membrane. The net amount of NaPi-Ha appears to be the result of an endocytotic rate regulated by a complex network of different protein kinases. New approaches demonstrated that NaPi-Ha is part of heteromeric protein complexes, organized by PDZ (postsynaptic protein PSD95, Drosophila junction protein Disc-large, tight junction protein ZO-1) proteins. Such complexes are thought to play important roles in the apical positioning and regulated endocytosis of NaPi-IIa and therefore such interactions have to be considered when explaining proximal phosphate ion reabsorption.

引用

页码：531 / 542

页数：12

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