Longitudinal Examination of Obesity and Cognitive Function: Results from the Baltimore Longitudinal Study of Aging

被引：265

作者：

Gunstad, John ^{[1
,2
]}

Lhotsky, April ^{[3
]}

Wendell, Carrington Rice ^{[3
]}

Ferrucci, Luigi ^{[4
]}

Zonderman, Alan B. ^{[3
]}

机构：

[1] Kent State Univ, Dept Psychol, Kent, OH 44242 USA

[2] Summa Hlth Syst, Dept Psychiat, Akron, OH USA

[3] NIA, Lab Personal & Cognit, NIH, Bethesda, MD 20892 USA

[4] NIA, Clin Res Branch, NIH, Bethesda, MD 20892 USA

来源：

NEUROEPIDEMIOLOGY | 2010年 / 34卷 / 04期

基金：

美国国家卫生研究院;

关键词：

Obesity; Cognition; Aged; Longitudinal; Age-associated cognitive change; BODY-MASS INDEX; VASCULAR RISK-FACTORS; HEALTHY OLDER-ADULTS; ALZHEIMER-DISEASE; UNITED-STATES; ABDOMINAL OBESITY; FAT DISTRIBUTION; FOLLOW-UP; WOMEN; WEIGHT;

D O I：

10.1159/000297742

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Obesity indices (i.e. BMI, waist-to-hip ratio) show differential relationships to other health outcomes, though their association to neurocognitive outcome is unclear. Methods: We examined whether central obesity would be more closely associated with cognitive function in 1,703 participants from the Baltimore Longitudinal Study of Aging. Results: Longitudinal mixed-effects regression models showed multiple obesity indices were associated with poorer performance in a variety of cognitive domains, including global screening measures, memory, and verbal fluency tasks. Obesity was associated with better performance on tests of attention and visuospatial ability. An obesity index by age interaction emerged in multiple domains, including memory and attention/executive function. Conclusion: Obesity indices showed similar associations to cognitive function, and further work is needed to clarify the physiological mechanisms that link obesity to poor neurocognitive outcome. Copyright (C) 2010 S. Karger AG, Basel

引用

页码：222 / 229

页数：8

共 55 条

[1]

Balakrishnan K, 2005, J ALZHEIMERS DIS, V8, P269

[2]

Barrett-Connor E, 1998, J Nutr Health Aging, V2, P113

[3] Neuroendocrine abnormalities in visceral obesity [J].

Björntorp, P ;

Rosmond, R .

INTERNATIONAL JOURNAL OF OBESITY, 2000, 24 (Suppl 2) :S80-S85

[4] Medical consequences of obesity [J].

Bray, GA .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2583-2589

[5] The effect of weight-loss dieting on cognitive performance and psychological well-being in overweight women [J].

Bryan, J ;

Tiggemann, M .

APPETITE, 2001, 36 (02) :147-156

[6] OBESITY, FAT DISTRIBUTION, AND WEIGHT-GAIN AS RISK-FACTORS FOR CLINICAL DIABETES IN MEN [J].

CHAN, JM ;

RIMM, EB ;

COLDITZ, GA ;

STAMPFER, MJ ;

WILLETT, WC .

DIABETES CARE, 1994, 17 (09) :961-969

[7] Fitness effects on the cognitive function of older adults: A meta-analytic study [J].

Colcombe, S ;

Kramer, AF .

PSYCHOLOGICAL SCIENCE, 2003, 14 (02) :125-130

[8] WEIGHT AS A RISK FACTOR FOR CLINICAL DIABETES IN WOMEN [J].

COLDITZ, GA ;

WILLETT, WC ;

STAMPFER, MJ ;

MANSON, JE ;

HENNEKENS, CH ;

ARKY, RA ;

SPEIZER, FE .

AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 132 (03) :501-513

[9] Reduced glucose tolerance is associated with poor memory performance and hippocampal atrophy among normal elderly [J].

Convit, A ;

Wolf, OT ;

Tarshish, C ;

de Leon, MJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (04) :2019-2022

[10] Cognitive reserve, age, and neuropsychological performance in healthy participants [J].

Corral, M ;

Rodríguez, M ;

Amenedo, E ;

Sánchez, JL ;

Díaz, F .

DEVELOPMENTAL NEUROPSYCHOLOGY, 2006, 29 (03) :479-491

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