Multiple mutations and cancer

被引：545

作者：

Loeb, LA ^{[1
]}

Loeb, KR

Anderson, JP

机构：

[1] Univ Washington, Sch Med, Dept Pathol, Joseph Gottstein Mem Canc Res Lab, Seattle, WA 98195 USA

[2] Fred Hutchinson Canc Res Ctr, Seattle, WA 98104 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 03期

关键词：

D O I：

10.1073/pnas.0334858100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most human tumors are highly heterogenous. We have hypothesized that this heterogeneity results from a mutator phenotype. Our premise is that normal mutation rates are insufficient to account for the multiple mutations found in human cancers, and, instead, that cancers must exhibit a mutator phenotype early during their evolution. Here, we examine the current status and implications of the mutator phenotype hypothesis for the prognosis, treatment, and prevention of human cancers.

引用

页码：776 / 781

页数：6

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