Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

被引:660
作者
Cho, Ae-Sim [2 ]
Jeon, Seon-Min [1 ]
Kim, Myung-Joo [3 ]
Yeo, Jiyoung [4 ]
Seo, Kwon-Il [5 ]
Choi, Myung-Sook [1 ]
Lee, Mi-Kyung [5 ]
机构
[1] Kyungpook Natl Univ, Dept Food Sci & Nutr, Taegu 702701, South Korea
[2] Sunchon Natl Univ, Grad Sch Educ, Dept Nutr Educ, Sunchon 540742, South Korea
[3] Daegu Polytech Coll, Dept Food Sci & Nutr, Taegu 706022, South Korea
[4] Pusan Natl Univ, Sch Oriental Med, Pusan 626810, South Korea
[5] Sunchon Natl Univ, Dept Food & Nutr, Sunchon 540742, South Korea
关键词
Chlorogenic acid; Caffeic acid; High-fat diet; Lipid metabolism; Obesity; CAFFEIC ACID; INSULIN SENSITIVITY; ADIPOSE-TISSUE; RAT-LIVER; ADIPONECTIN; CHOLESTEROL; PROTEIN; HYPOADIPONECTINEMIA; CARCINOGENESIS; ASSOCIATION;
D O I
10.1016/j.fct.2010.01.003
中图分类号
TS2 [食品工业];
学科分类号
0832 ;
摘要
This study investigated the efficacy of chlorogenic acid on altering body fat in high-fat diet (37% calories from fat) induced-obese mice compared to caffeic acid. Caffeic acid or chlorogenic acid was supplemented with high-fat diet at 0.02% (wt/wt) dose. Both caffeic acid and chlorogenic acid significantly lowered body weight, visceral fat mass and plasma leptin and insulin levels compared to the high-fat control group. They also lowered triglyceride (in plasma, liver and heart) and cholesterol (in plasma, adipose tissue and heart) concentrations. Triglyceride content in adipose tissue was significantly lowered, whereas the plasma adiponectin level was elevated by chlorogenic acid supplementation compared to the high-fat control group. Body weight was significantly correlated with plasma leptin (r = 0.894. p < 0.01) and insulin (r = 0.496, p < 0.01) levels, respectively. Caffeic acid and chlorogenic acid significantly inhibited fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and acyl-CoA: cholesterol acyltransferase activities, while they increased fatty acid beta-oxidation activity and peroxisome proliferator-activated receptors alpha expression in the liver compared to the high-fat group. These results suggest that caffeic acid and chlorogenic acid improve body weight, lipid metabolism and obesity-related hormones levels in high-fat fed mice. Chlorogenic acid seemed to be more potent for body weight reduction and regulation of lipid metabolism than caffeic acid. (C) 2010 Elsevier Ltd. All rights reserved.
引用
收藏
页码:937 / 943
页数:7
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