Magnetically Responsive Smart Nanoparticles for Cancer Treatment with a Combination of Magnetic Hyperthermia and Remote-Control Drug Release

被引：176

作者：

Hayashi, Koichiro ^{[1
,5
]}

Nakamura, Michihiro ^{[1
]}

Miki, Hirokazu ^{[2
]}

Ozaki, Shuji ^{[3
]}

Abe, Masahiro ^{[4
]}

Matsumoto, Toshio ^{[4
]}

Sakamoto, Wataru ^{[5
]}

Yogo, Toshinobu ^{[5
]}

Ishimura, Kazunori ^{[1
]}

机构：

[1] Univ Tokushima, Grad Sch, Inst Hlth Biosci, Dept Anat & Cell Biol, Tokushima 7708503, Japan

[2] Tokushima Univ Hosp, Div Transfus Med, Tokushima 7700042, Japan

[3] Tokushima Prefectural Cent Hosp, Dept Internal Med, Tokushima 7700042, Japan

[4] Univ Tokushima, Grad Sch Med Sci, Dept Med & Bioregulatory Sci, Tokushima 7708503, Japan

[5] Nagoya Univ, EcoTopia Sci Inst, Div Nanomat Sci, Chikusa Ku, Nagoya, Aichi 4648603, Japan

来源：

THERANOSTICS | 2014年 / 4卷 / 08期

基金：

日本学术振兴会;

关键词：

smart nanoparticles; alternating current magnetic field; cancer cells; IRON-OXIDE NANOCUBES; HYBRID; NANOCARRIERS; RESONANCE; DESIGN; MAGNETOLIPOSOMES; NANOSTRUCTURES; IMMUNOTHERAPY; THERANOSTICS; LIPOSOMES;

D O I：

10.7150/thno.9199

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

We report the synthesis of smart nanoparticles (NPs) that generate heat in response to an alternating current magnetic field (ACMF) and that sequentially release an anticancer drug (doxorubicin, DOX). We further study the in vivo therapeutic efficacy of the combination of magnetic hyperthermia (MHT) and chemotherapy using the smart NPs for the treatment of multiple myeloma. The smart NPs are composed of a polymer with a glass-transition temperature (Tg) of 44 degrees C, which contains clustered Fe3O4 NPs and DOX. The clustered Fe3O4 NPs produce heat when the ACMF is applied and rise above 44 degrees C, which softens the polymer phase and leads to the release of DOX. The combination of MHT and chemotherapy using the smart NPs destroys cancer cells in the entire tumor and achieves a complete cure in one treatment without the recurrence of malignancy. Furthermore, the smart NPs have no significant toxicity.

引用

页码：834 / 844

页数：11

共 55 条

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Chains of Magnetosomes Extracted from AMB-1 Magnetotactic Bacteria for Application in Alternative Magnetic Field Cancer Therapy [J].