The E2F family: specific functions and overlapping interests

被引：454

作者：

Attwooll, C

Denchi, EL

Helin, K

机构：

[1] Biotech Res & Innovat Ctr, DK-2100 Copenhagen, Denmark

[2] European Inst Oncol, Dept Expt Oncol, Milan, Italy

来源：

EMBO JOURNAL | 2004年 / 23卷 / 24期

关键词：

cancer; cell cycle; E2F; pRB; transcription;

D O I：

10.1038/sj.emboj.7600481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The E2F transcription factors are key regulators of cell cycle progression and the E2F field has made rapid advances since its advent in 1986. Yet, while our understanding of the roles and functions of the E2F family has made enormous progress, with each discovery new questions arise. In this review, we summarise the most recent advances in the field and discuss the remaining key questions. In particular, we will focus on how specificity is achieved among the E2Fs.

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收藏

页码：4709 / 4716

页数：8

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