Total synthesis of methyl protodioscin: A potent agent with antitumor activity

被引：70

作者：

Cheng, MS

Wang, QL

Tian, Q

Song, HY

Liu, YX

Li, Q

Xu, X

Miao, HD

Yao, XS

Yang, Z

机构：

[1] Shenyang Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China

[2] Peking Univ, Key Lab Bioorgan Chem & Mol Engn, Minist Educ, Dept Biol Chem,Coll Chem, Beijing 100871, Peoples R China

[3] VivoQuest Inc, New York, NY 10989 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2003年 / 68卷 / 09期

关键词：

D O I：

10.1021/jo020683w

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Methyl protodioscin (1), otherwise known as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-{alpha-L-rhamnopyranosyl-(1-->4) }-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-22-methoxy-25(R)-furost-5-ene-3beta,26-diol, has been synthesized for the first time from diosgenin through nine steps in an overall yield of 7.8%.

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页码：3658 / 3662

页数：5

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