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Peroxisome proliferator-activated receptor agonists

被引：166
作者：
Willson, TM
Wahli, W
机构：
[1] Glaxo Wellcome Inc, Res & Dev, Res Triangle Pk, NC 27709 USA
[2] Univ Lausanne, Inst Biol Anim, CH-1015 Lausanne, Switzerland
来源：
CURRENT OPINION IN CHEMICAL BIOLOGY | 1997年 / 1卷 / 02期
关键词：
D O I：
10.1016/S1367-5931(97)80015-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The peroxisome proliferator-activated receptors are a family of three ligand-activated transcription factors, Fibrate antihyperlipidemic drugs and thiazolidinedione antihyperglycemic drugs were recently identified as synthetic ligands for these receptors. In addition, certain unsaturated fatty acids and eicosanoids were shown to bind the receptors, and thus represent naturally occurring PPAR ligands. The synthetic and natural ligands have proven to be powerful tools in dissecting the biology of these orphan receptors. (C) Current Biology Ltd ISSN 1367-5931.
引用
收藏
页码：235 / 241
页数：7
相关论文
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