Evidence for biliary excretion of vancomycin into stool during intravenous therapy: Potential implications for rectal colonization with vancomycin-resistant enterococci

被引:43
作者
Currie, BP
Lemos, L
机构
[1] Montefiore Med Ctr, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Dept Med, Div Infect Dis, Bronx, NY 10467 USA
[3] Albert Einstein Coll Med, Bronx, NY 10467 USA
关键词
D O I
10.1128/AAC.48.11.4427-4429.2004
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Sixty-three stool samples and five bile samples were prospectively collected from 33 patients receiving intravenous vancomycin therapy and were quantitatively analyzed for vancomycin by a competitive immunoassay. Vancomycin was excreted via bile into the stools of almost all patients at concentrations of 3.3 to 94.8 mug/ml after greater than or equal to 5 days of a therapy of 1 g every 12 h.
引用
收藏
页码:4427 / 4429
页数:3
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