The present view of the mechanism of protein folding

被引：332

作者：

Daggett, V

Fersht, A

机构：

[1] Univ Washington, Dept Med Chem, Seattle, WA 98195 USA

[2] Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England

[3] MRC Ctr, Ctr Prot Engn, Cambridge CB2 2QH, England

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 06期

基金：

英国医学研究理事会; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1126

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We can track the positions and movements of all the atoms in small proteins as they fold and unfold by combining experimental studies with atomic-resolution molecular dynamics simulations. General principles as to how such complex architectures form so rapidly are now emerging from in-depth studies of a few proteins.

引用

页码：497 / 502

页数：7

共 53 条

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