HIV-1 protease inhibitors and the MDR1 multidrug transporter

被引:56
作者
Lee, CGL [1 ]
Gottesman, MM [1 ]
机构
[1] NCI, Cell Biol Lab, NIH, Bethesda, MD 20892 USA
关键词
D O I
10.1172/JCI2575
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
引用
收藏
页码:287 / 288
页数:2
相关论文
共 13 条
[1]   Presence of an inducible HIV-1 latent reservoir during highly active antiretroviral therapy [J].
Chun, TW ;
Stuyver, L ;
Mizell, SB ;
Ehler, LA ;
Mican, JAM ;
Baseler, M ;
Lloyd, AL ;
Nowak, MA ;
Fauci, AS .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (24) :13193-13197
[2]   THE 3 MOUSE MULTIDRUG RESISTANCE (MDR) GENES ARE EXPRESSED IN A TISSUE-SPECIFIC MANNER IN NORMAL MOUSE-TISSUES [J].
CROOP, JM ;
RAYMOND, M ;
HABER, D ;
DEVAULT, A ;
ARCECI, RJ ;
GROS, P ;
HOUSMAN, DE .
MOLECULAR AND CELLULAR BIOLOGY, 1989, 9 (03) :1346-1350
[3]   2 MEMBERS OF THE MOUSE MDR GENE FAMILY CONFER MULTIDRUG RESISTANCE WITH OVERLAPPING BUT DISTINCT DRUG SPECIFICITIES [J].
DEVAULT, A ;
GROS, P .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (04) :1652-1663
[4]  
DRACH D, 1992, BLOOD, V80, P2729
[5]   Identification of a reservoir for HIV-1 in patients on highly active antiretroviral therapy [J].
Finzi, D ;
Hermankova, M ;
Pierson, T ;
Carruth, LM ;
Buck, C ;
Chaisson, RE ;
Quinn, TC ;
Chadwick, K ;
Margolick, J ;
Brookmeyer, R ;
Gallant, J ;
Markowitz, M ;
Ho, DD ;
Richman, DD ;
Siliciano, RF .
SCIENCE, 1997, 278 (5341) :1295-1300
[6]   BIOCHEMISTRY OF MULTIDRUG-RESISTANCE MEDIATED BY THE MULTIDRUG TRANSPORTER [J].
GOTTESMAN, MM ;
PASTAN, I .
ANNUAL REVIEW OF BIOCHEMISTRY, 1993, 62 :385-427
[7]   Is P-glycoprotein a sufficient marker for multidrug resistance in vivo? Immunohistochemical staining for P-glycoprotein in children and adult leukemia: Correlation with clinical outcome [J].
Kaczorowski, S ;
Ochocka, M ;
Kaczorowska, M ;
Aleksandrowicz, R ;
Matysiakl, M ;
Karwacki, M .
LEUKEMIA & LYMPHOMA, 1995, 20 (1-2) :143-152
[8]   The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors [J].
Kim, RB ;
Fromm, MF ;
Wandel, C ;
Leake, B ;
Wood, AJJ ;
Roden, DM ;
Wilkinson, GR .
JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (02) :289-294
[9]   Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833 [J].
Mayer, U ;
Wagenaar, E ;
Dorobek, B ;
Beijnen, JH ;
Borst, P ;
Schinkel, AH .
JOURNAL OF CLINICAL INVESTIGATION, 1997, 100 (10) :2430-2436
[10]   Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins [J].
Schinkel, AH ;
Mayer, U ;
Wagenaar, E ;
Mol, CAAM ;
vanDeemter, L ;
Smit, JJM ;
vanderValk, MA ;
Voordouw, AC ;
Spits, H ;
vanTellingen, O ;
Zijlmans, JMJM ;
Fibbe, WE ;
Borst, P .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :4028-4033