Versatile polyketide enzymatic machinery for the biosynthesis of complex mycobacterial lipids

被引：86

作者：

Gokhale, Rajesh S. ^{[1
]}

Saxena, Priti ^{[1
]}

Chopra, Tarun ^{[1
]}

Mohanty, Debasisa ^{[1
]}

机构：

[1] Natl Inst Immunol, New Delhi 110067, India

来源：

NATURAL PRODUCT REPORTS | 2007年 / 24卷 / 02期

关键词：

D O I：

10.1039/b616817p

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cell envelope of Mycobacterium tuberculosis (Mtb) is a treasure house of a variety of biologically active molecules with fascinating architectures. The decoding of the genetic blueprint of Mtb in recent years has provided the impetus for dissecting the metabolic pathways involved in the biosynthesis of lipidic metabolites. The focus of this Highlight is to emphasize the functional role of polyketide synthase (PKS) proteins in the biosynthesis of complex mycobacterial lipids. The catalytic as well as mechanistic versatility of PKSs in generating metabolic diversity and the significance of recently discovered fatty acyl-AMP ligases in establishing "biochemical crosstalk" between fatty acid synthases (FASs) and PKSs is described. The phenotypic heterogeneity and remodeling of the mycobacterial cell wall in its aetiopathogenesis is discussed.

引用

页码：267 / 277

页数：11

共 129 条

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