α-amino acid induced rate acceleration in aqueous biphasic Lewis acid catalyzed Michael addition reactions

被引：40

作者：

Aplander, Karolina

Ding, Rui

Lindstroem, U. Marcus

Wennerberg, Johan

Schultz, Sara

机构：

[1] McGill Univ, Dept Chem, Montreal, PQ H3A 2K6, Canada

[2] DuPont Chemoswed, S-20180 Malmo, Sweden

[3] Lund Univ, Div Organ Chem, S-22100 Lund, Sweden

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 24期

关键词：

amino acids; aqueous media; Lewis acid catalysis; ligand effects; Michael addition;

D O I：

10.1002/anie.200700560

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

It's as easy as ABC: α-Amino acids may become very important tools in the development of economical and environmentally friendly aqueous biphasic catalysis. Alanine accelerated an Yb(OTf)3-catalyzed Michael addition by a factor of 138. The solubilizing and stabilizing properties of alanine allowed the metal catalyst to be heterogenized" in the aqueous phase and recycled multiple times without appreciable loss of activity. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA."

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页码：4543 / 4546

页数：4

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