Blockade of brain type II interleukin-1 receptors potentiates IL1β-induced anorexia in mice

被引：18

作者：

Cremona, S ^{[1
]}

Layé, S ^{[1
]}

Dantzer, R ^{[1
]}

Parnet, P ^{[1
]}

机构：

[1] INSERM, U394, F-33077 Bordeaux, France

来源：

NEUROSCIENCE LETTERS | 1998年 / 246卷 / 02期

关键词：

IL1; beta; receptors; food intake; rectal temperature; brain; mouse;

D O I：

10.1016/S0304-3940(98)00238-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Interleukin-1 beta (IL1 beta) peripheral activities are mediated by type I IL1 receptors (IL1RI), whereas type II IL1 receptors (IL1RII) act as 'decoy' targets. To study the functionality of IL1RII in the brain, mice were treated with an intracerebroventricular injection of a neutralising MoAb directed against IL1RII (4E2, 1 mu g) followed by recombinant rat IL1 beta at a dose (2 ng) that produced a moderate but significant decrease of food intake 1 h 30 min after injection. The administration of 4E2 to IL-1 beta treated mice significantly potentiated IL1 beta-induced decrease in food intake without altering hypothermia. The effects of IL1 beta were abrogated in the positive control group treated with IL1ra (2 mu g, i.c.v). These results suggest that brain IL1RII down-regulate the effects of IL1 beta on its cell targets in the brain. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：101 / 104

页数：4

共 20 条

[1] INTERLEUKIN-1 RECEPTOR ANTAGONIST - A NEW MEMBER OF THE INTERLEUKIN-1 FAMILY [J].