MONOCLONAL-ANTIBODY 1994-01 (ALSO KNOWN AS ALVA-42) REPORTED TO RECOGNIZE TYPE-II IL-1 RECEPTOR IS SPECIFIC FOR HLA-DR ALPHA-CHAIN AND BETA-CHAIN

被引：22

作者：

GAYLE, MA

SIMS, JE

DOWER, SK

SLACK, JL

机构：

[1] Immunex Research and Development Corporation, Seattle

来源：

CYTOKINE | 1994年 / 6卷 / 01期

关键词：

DIRECT EXPRESSION CLONING; MHC CLASS II ANTIGEN; MONOCLONAL ANTIBODY; TYPE II IL-1 RECEPTOR;

D O I：

10.1016/1043-4666(94)90012-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Monoclonal antibody (MAb) 1994-01 has been reported to bind to the human type II Interleukin 1 (IL-1) receptor and in so doing block IL-1 binding in vitro and certain IL-1 mediated responses in vivo. While this antibody binds to a type II IL-1 receptor positive cell line, it can be shown that it does not bind to the type II IL-1 receptor. By direct expression cloning, we have identified two gene products, both of which are required for binding of this antibody. The two proteins are the α and β subunits of the MHC class II antigen HLA-DR. © 1994.

引用

页码：83 / 86

页数：4

共 11 条

[1]

ARMELLINI D, 1992, SERONO SYM, V92, P355

[2]

BENJAMIN D, 1990, BLOOD, V75, P2017

[3] T-CELL INTERLEUKIN-1 RECEPTOR CDNA EXPRESSED IN CHINESE-HAMSTER OVARY CELLS REGULATES FUNCTIONAL-RESPONSES TO INTERLEUKIN-1 [J].

CURTIS, BM ;

GALLIS, B ;

OVERELL, RW ;

MCMAHAN, CJ ;

DEROOS, P ;

IRELAND, R ;

EISENMAN, J ;

DOWER, SK ;

SIMS, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (09) :3045-3049

[4] DETECTION AND CHARACTERIZATION OF HIGH-AFFINITY PLASMA-MEMBRANE RECEPTORS FOR HUMAN INTERLEUKIN-1 [J].

DOWER, SK ;

KRONHEIM, SR ;

MARCH, CJ ;

CONLON, PJ ;

HOPP, TP ;

GILLIS, S ;

URDAL, DL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (02) :501-515

[5]

GHIARA P, 1991, Cytokine, V3, P473, DOI 10.1016/1043-4666(91)90188-J

[6] PURIFICATION AND CHARACTERIZATION OF HUMAN INTERLEUKIN-1 EXPRESSED IN ESCHERICHIA-COLI [J].

KRONHEIM, SR ;

CANTRELL, MA ;

DEELEY, MC ;

MARCH, CJ ;

GLACKIN, PJ ;

ANDERSON, DM ;

HEMENWAY, T ;

MERRIAM, JE ;

COSMAN, D ;

HOPP, TP .

BIO-TECHNOLOGY, 1986, 4 (12) :1078-1082

[7] A NOVEL IL-1 RECEPTOR, CLONED FROM B-CELLS BY MAMMALIAN EXPRESSION, IS EXPRESSED IN MANY CELL-TYPES [J].

MCMAHAN, CJ ;

SLACK, JL ;

MOSLEY, B ;

COSMAN, D ;

LUPTON, SD ;

BRUNTON, LL ;

GRUBIN, CE ;

WIGNALL, JM ;

JENKINS, NA ;

BRANNAN, CI ;

COPELAND, NG ;

HUEBNER, K ;

CROCE, CM ;

CANNIZZARRO, LA ;

BENJAMIN, D ;

DOWER, SK ;

SPRIGGS, MK ;

SIMS, JE .

EMBO JOURNAL, 1991, 10 (10) :2821-2832

[8]

SEGAL DM, 1977, J IMMUNOL, V118, P1338

[9] INTERLEUKIN-1 SIGNALING OCCURS EXCLUSIVELY VIA THE TYPE-I RECEPTOR [J].

SIMS, JE ;

GAYLE, MA ;

SLACK, JL ;

ALDERSON, MR ;

BIRD, TA ;

GIRI, JG ;

COLOTTA, F ;

RE, F ;

MANTOVANI, A ;

SHANEBECK, K ;

GRABSTEIN, KH ;

DOWER, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (13) :6155-6159

[10] CLONING THE INTERLEUKIN-1 RECEPTOR FROM HUMAN T-CELLS [J].

SIMS, JE ;

ACRES, RB ;

GRUBIN, CE ;

MCMAHAN, CJ ;

WIGNALL, JM ;

MARCH, CJ ;

DOWER, SK .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :8946-8950

← 1 2 →