MONOCLONAL-ANTIBODY 1994-01 (ALSO KNOWN AS ALVA-42) REPORTED TO RECOGNIZE TYPE-II IL-1 RECEPTOR IS SPECIFIC FOR HLA-DR ALPHA-CHAIN AND BETA-CHAIN

被引:22
作者
GAYLE, MA
SIMS, JE
DOWER, SK
SLACK, JL
机构
[1] Immunex Research and Development Corporation, Seattle
关键词
DIRECT EXPRESSION CLONING; MHC CLASS II ANTIGEN; MONOCLONAL ANTIBODY; TYPE II IL-1 RECEPTOR;
D O I
10.1016/1043-4666(94)90012-4
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Monoclonal antibody (MAb) 1994-01 has been reported to bind to the human type II Interleukin 1 (IL-1) receptor and in so doing block IL-1 binding in vitro and certain IL-1 mediated responses in vivo. While this antibody binds to a type II IL-1 receptor positive cell line, it can be shown that it does not bind to the type II IL-1 receptor. By direct expression cloning, we have identified two gene products, both of which are required for binding of this antibody. The two proteins are the α and β subunits of the MHC class II antigen HLA-DR. © 1994.
引用
收藏
页码:83 / 86
页数:4
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