MONOCLONAL-ANTIBODY 1994-01 (ALSO KNOWN AS ALVA-42) REPORTED TO RECOGNIZE TYPE-II IL-1 RECEPTOR IS SPECIFIC FOR HLA-DR ALPHA-CHAIN AND BETA-CHAIN

Monoclonal antibody (MAb) 1994-01 has been reported to bind to the human type II Interleukin 1 (IL-1) receptor and in so doing block IL-1 binding in vitro and certain IL-1 mediated responses in vivo. While this antibody binds to a type II IL-1 receptor positive cell line, it can be shown that it does not bind to the type II IL-1 receptor. By direct expression cloning, we have identified two gene products, both of which are required for binding of this antibody. The two proteins are the α and β subunits of the MHC class II antigen HLA-DR. © 1994.