T follicular helper and TH2 cells in allergic responses

被引：41

作者：

Kubo, Masato ^{[1
,2
]}

机构：

[1] Tokyo Univ Sci, Res Inst Biomed Sci, Div Mol Pathol, Noda, Chiba, Japan

[2] RIKEN, Yokohama Inst, Res Ctr Integrat Med Sci IMS, Lab Cytokine Regulat, Yokohama, Kanagawa, Japan

来源：

ALLERGOLOGY INTERNATIONAL | 2017年 / 66卷 / 03期

关键词：

Allergen-specific T cell; IL-4; Immunoglobulin E (IgE); Th2; cytokines; TH2 CYTOKINE LOCUS; DENDRITIC CELLS; B-CELLS; TRANSCRIPTION; DIFFERENTIATION; INDUCTION; INTERLEUKIN-4; EXPRESSION; IMMUNITY; IL-21;

D O I：

10.1016/j.alit.2017.04.006

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

IL-4 is a cytokine commonly secreted by T(H)2 and follicular helper T (T-FH) cells after antigenic sensitization. T(H)2 cells have been thought to be the major contributor of B cell help as a source of IL-4 responsible for class switch recombination to Immunoglobulin G1 (IgG1) and Immunoglobulin E (IgE). Importantly, there are some differences in transcriptional regulation between these two T cell subsets. The IL-4 production by T(H)2 and TFH cells is distinctively regulated by two pathways, GATA-3-mediated Il4-HS2 enhancer and Notch mediated Il4-CNS-2 enhancer. IgE and IgG1 antibody responses are mainly controlled by IL-4-secreting TFH cells, but not by T(H)2 cells. In this review, we discuss the role of TH2 and T-FH cells in IgE production and allergic responses. Copyright (C) 2017, Japanese Society of Allergology. Production and hosting by Elsevier B.V.

引用

页码：377 / 381

页数：5

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