Versatile Dde-based primary amine linkers for solid phase synthesis

被引：33

作者：

Chhabra, SR ^{[1
]}

Khan, AN ^{[1
]}

Bycroft, BW ^{[1
]}

机构：

[1] Univ Nottingham, Sch Pharmaceut Sci, Nottingham NG7 2RD, England

来源：

TETRAHEDRON LETTERS | 1998年 / 39卷 / 21期

关键词：

amines; solid-phase synthesis; supported reagents/reactions;

D O I：

10.1016/S0040-4039(98)00555-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Linkers based on the Dde primary amine protecting strategy have been developed and their utility demonstrated in the solid phase synthesis of a naturally occurring spider toxin. The linkers are stable to both acid and base conditions and cleaved either with 2% v/v hydrazine hydrate or by transamination with a volatile primary alkylamine in a variety of organic solvents. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：3585 / 3588

页数：4

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