Does carbamazepine have a narrow therapeutic plasma concentration range?

被引：46

作者：

Bialer, M

Levy, RH

Perucca, E

机构：

[1] Hebrew Univ Jerusalem, Fac Med, Dept Pharmaceut, IL-91120 Jerusalem, Israel

[2] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, David R Bloom Ctr Pharm, IL-91120 Jerusalem, Israel

[3] Univ Washington, Sch Med, Dept Neurol Surg, Seattle, WA 98195 USA

[4] Univ Washington, Sch Pharm, Dept Pharmaceut, Seattle, WA 98195 USA

[5] Univ Pavia, Dept Internal Med & Therapeut, Clin Pharmacol Unit, I-27100 Pavia, Italy

来源：

THERAPEUTIC DRUG MONITORING | 1998年 / 20卷 / 01期

关键词：

carbamazepine; narrow therapeutic index (NTI) drugs; therapeutic range;

D O I：

10.1097/00007691-199802000-00010

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Recently, there has been considerable discussion regarding the classification of drugs as a function of their therapeutic index, defined as the ratio between the upper and lower limits of the therapeutic range. Pharmacologic agents with a therapeutic index <2 are classified as "narrow therapeutic index" (NTI) drugs, One of the agents classified as an NTI drug is carbamazepine. These recent developments led us to evaluate critically the evidence supporting the classification of carbamazepine as an NTI drug to address an old question: "Does carbamazepine have a narrow therapeutic plasma concentration range?"

引用

页码：56 / 59

页数：4

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